3lu8: Difference between revisions

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-{{Seed}}
-[[Image:3lu8.jpg|left|200px]]
-<!--
+==Human serum albumin in complex with compound 3==
-The line below this paragraph, containing "STRUCTURE_3lu8", creates the "Structure Box" on the page.
+<StructureSection load='3lu8' size='340' side='right'caption='[[3lu8]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3lu8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LU8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LU8 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IQX:N-[5-(5-{[(2,4-DIMETHYL-1,3-THIAZOL-5-YL)SULFONYL]AMINO}-6-FLUOROPYRIDIN-3-YL)-4-METHYL-1,3-THIAZOL-2-YL]ACETAMIDE'>IQX</scene></td></tr>
-{{STRUCTURE_3lu8|  PDB=3lu8  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lu8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lu8 OCA], [https://pdbe.org/3lu8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lu8 RCSB], [https://www.ebi.ac.uk/pdbsum/3lu8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lu8 ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[https://omim.org/entry/103600 103600]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The displacement of probes that bind selectively to subdomains IIA or IIIA on human serum albumin (HSA) by competing compounds has been followed using fluorescence spectroscopy, and has therefore been used to assign a primary binding site for these compounds in the presence and absence of fatty acids. The crystal structures have also been solved for three compounds: a matched pair of carboxylic acids whose binding strength to HSA unexpectedly decreased as the lipophilicity increased; and a highly bound sulphonamide that appeared not to displace the probes in the displacement assay. The crystallography results support the findings from the fluorescence displacement assay. The results indicate that drug binding to subdomain IB might also be important location for certain compounds.
-===Human serum albumin in complex with compound 3===
+A combined spectroscopic and crystallographic approach to probing drug-human serum albumin interactions.,Buttar D, Colclough N, Gerhardt S, MacFaul PA, Phillips SD, Plowright A, Whittamore P, Tam K, Maskos K, Steinbacher S, Steuber H Bioorg Med Chem. 2010 Nov 1;18(21):7486-96. Epub 2010 Sep 24. PMID:20869876<ref>PMID:20869876</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 3lu8" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_20869876}}, adds the Publication Abstract to the page
+*[[Albumin 3D structures|Albumin 3D structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 20869876 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_20869876}}
+__TOC__
+</StructureSection>
-==About this Structure==
-LU8 is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LU8 OCA].
-==Reference==
-<ref group="xtra">PMID:20869876</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Buttar, D.]]
+[[Category: Large Structures]]
-[[Category: Colclough, N.]]
+[[Category: Buttar D]]
-[[Category: Gerhardt, S.]]
+[[Category: Colclough N]]
-[[Category: MacFaul, P A.]]
+[[Category: Gerhardt S]]
-[[Category: Maskos, K.]]
+[[Category: MacFaul PA]]
-[[Category: Phillips, S D.]]
+[[Category: Maskos K]]
-[[Category: Plowright, A.]]
+[[Category: Phillips SD]]
-[[Category: Steinbacher, S.]]
+[[Category: Plowright A]]
-[[Category: Steuber, H.]]
+[[Category: Steinbacher S]]
-[[Category: Tam, K.]]
+[[Category: Steuber H]]
-[[Category: Whittamore, P.]]
+[[Category: Tam K]]
-[[Category: Astrazeneca]]
+[[Category: Whittamore P]]
-[[Category: Binding site]]
-[[Category: Drug design]]
-[[Category: Hsa]]
-[[Category: Ligand]]
-[[Category: Protein binding]]
-[[Category: Proteros biostructures gmbh]]
-[[Category: Serum albumin]]
-[[Category: Transport protein]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 27 12:10:38 2010''