3ltg: Difference between revisions

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 ==Crystal structure of the Drosophila Epidermal Growth Factor Receptor ectodomain complexed with a low affinity Spitz mutant==
-<StructureSection load='3ltg' size='340' side='right' caption='[[3ltg]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
+<StructureSection load='3ltg' size='340' side='right'caption='[[3ltg]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[3ltg]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LTG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LTG FirstGlance]. <br>
+<table><tr><td colspan='2'>[[3ltg]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LTG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LTG FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3i2t|3i2t]], [[3ltf|3ltf]], [[3ca7|3ca7]]</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">torpedo; dEGFR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME]), Spitz ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ltg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ltg OCA], [https://pdbe.org/3ltg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ltg RCSB], [https://www.ebi.ac.uk/pdbsum/3ltg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ltg ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ltg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ltg OCA], [http://pdbe.org/3ltg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ltg RCSB], [http://www.ebi.ac.uk/pdbsum/3ltg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ltg ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/EGFR_DROME EGFR_DROME]] Binds to four ligands: Spitz, Gurken, Vein and Argos, which is an antagonist. Transduces the signal through the ras-raf-MAPK pathway. Involved in a myriad of developmental decisions. Critical for the proliferation of imaginal tissues, and for the determination of both the antero-posterior and dorso-ventral polarities of the oocyte. In the embryo, plays a role in the establishment of ventral cell fates, maintenance of amnioserosa and ventral neuroectodermal cells, germ band retraction, cell fate specification in the central nervous system and production of cuticle. Required for embryonic epithelial tissue repair.<ref>PMID:22140578</ref>  [[http://www.uniprot.org/uniprot/SPITZ_DROME SPITZ_DROME]] Ligand for the EGF receptor (Gurken). Involved in a number of unrelated developmental choices, for example, dorsal-ventral axis formation, glial migration, sensory organ determination, and muscle development. It is required for photoreceptor determination.<ref>PMID:7833286</ref>
+[https://www.uniprot.org/uniprot/EGFR_DROME EGFR_DROME] Binds to four ligands: Spitz, Gurken, Vein and Argos, which is an antagonist. Transduces the signal through the ras-raf-MAPK pathway. Involved in a myriad of developmental decisions. Critical for the proliferation of imaginal tissues, and for the determination of both the antero-posterior and dorso-ventral polarities of the oocyte. In the embryo, plays a role in the establishment of ventral cell fates, maintenance of amnioserosa and ventral neuroectodermal cells, germ band retraction, cell fate specification in the central nervous system and production of cuticle. Required for embryonic epithelial tissue repair.<ref>PMID:22140578</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
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    <jmolCheckbox>
      <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lt/3ltg_consurf.spt"</scriptWhenChecked>
-     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
      <text>to colour the structure by Evolutionary Conservation</text>
    </jmolCheckbox>
@@ Line 31: / Line 30: @@
 ==See Also==
-*[[Epidermal Growth Factor Receptor|Epidermal Growth Factor Receptor]]
+*[[Epidermal growth factor receptor 3D structures|Epidermal growth factor receptor 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Drome]]
+[[Category: Drosophila melanogaster]]
-[[Category: Alvarado, D]]
+[[Category: Large Structures]]
-[[Category: Klein, D E]]
+[[Category: Alvarado D]]
-[[Category: Lemmon, M A]]
+[[Category: Klein DE]]
-[[Category: Atp-binding]]
+[[Category: Lemmon MA]]
-[[Category: Cell membrane]]
-[[Category: Developmental protein]]
-[[Category: Differentiation]]
-[[Category: Disulfide bond]]
-[[Category: Egf-like domain]]
-[[Category: Endoplasmic reticulum]]
-[[Category: Glycoprotein]]
-[[Category: Golgi apparatus]]
-[[Category: Kinase]]
-[[Category: Membrane]]
-[[Category: Neurogenesis]]
-[[Category: Nucleotide-binding]]
-[[Category: Receptor]]
-[[Category: Receptor-ligand complex ectodomain cysteine rich domain egf domain]]
-[[Category: Transferase]]
-[[Category: Transferase-transferase regulator complex]]
-[[Category: Transmembrane]]
-[[Category: Tyrosine-protein kinase]]