5hca: Difference between revisions

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 ==Globular Domain of the Entamoeba histolytica calreticulin in complex with glucose==
-<StructureSection load='5hca' size='340' side='right' caption='[[5hca]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
+<StructureSection load='5hca' size='340' side='right'caption='[[5hca]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5hca]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HCA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HCA FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5hca]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Entamoeba_histolytica_HM-1:IMSS Entamoeba histolytica HM-1:IMSS]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HCA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HCA FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hca FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hca OCA], [http://pdbe.org/5hca PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hca RCSB], [http://www.ebi.ac.uk/pdbsum/5hca PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hca ProSAT]</span></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hca FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hca OCA], [https://pdbe.org/5hca PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hca RCSB], [https://www.ebi.ac.uk/pdbsum/5hca PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hca ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/CALR_ENTH1 CALR_ENTH1] Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle (By similarity). This lectin may interact transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (By similarity). Plays a role in host cell phagocytosis, possibly by acting as a receptor for host C1q (PubMed:22473608). Binding to C1q prevents the activation of the host classical complement pathway (PubMed:24860808). Also, binds to apoptotic host cells independently of host C1q and collectins (PubMed:22473608).[UniProtKB:P27797]<ref>PMID:22473608</ref> <ref>PMID:24860808</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 16: / Line 19: @@
 </div>
 <div class="pdbe-citations 5hca" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Calreticulin 3D structures|Calreticulin 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: GABORIAUD, C]]
+[[Category: Entamoeba histolytica HM-1:IMSS]]
-[[Category: MOREAU, C P]]
+[[Category: Large Structures]]
-[[Category: Chaperone]]
+[[Category: Gaboriaud C]]
-[[Category: Legume lectin domain]]
+[[Category: Moreau CP]]
-[[Category: Sugar binding protein]]