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[[Image:SSU front and LSU front side by side white backgroundSMALL.jpg|middle|500px]]<br>
<StructureSection load='4v42' size='450' side='right' scene='User:Wayne_Decatur/SandboxRibosome/Bothmodels6/1' caption='The Ribosome ([[4v42]])'>
 
__TOC__
 
[[Image:Screen capture of 70S white background spacefill tRNAS.jpg|left|300px]]<br />
 
 
 
'''The Ribosome'''<br>
'''The protein synthesis machine of cells''' <br>
'''shown with the 3 transfer RNAs and messenger RNA bound.'''
 
 
 
 
==Introduction==
==Introduction==
<table width='550' align='right' cellpadding='5'><tr><td rowspan='2'>&nbsp;</td><td bgcolor='#eeeeee'><applet load='1jgo1giy.gz.pdb' size='540' frame='true' align='right' scene='User:Wayne_Decatur/SandboxRibosome/Bothmodels6/1' /></td></tr><tr><td bgcolor='#eeeeee'><center>'''The Ribosome''' ([[1jgo]] and [[1giy]]), resolution 5.5&Aring; (<scene name='User:Wayne_Decatur/SandboxRibosome/Bothmodels6/1'>initial scene</scene>). <br>
·· {{Link Toggle 70SribotRNAs}} ·· {{Link Toggle 70SribomRNA}} ·· {{Link Toggle 70SriborRNA}} ·· {{Link Toggle 70SriboProtein}} ··<br>
·· {{Link Toggle 70SriboAsitetRNA}} ·· {{Link Toggle 70SriboPsitetRNA}} ·· {{Link Toggle 70SriboEsitetRNA}} ·· <br>
·· {{Link Toggle 70SriboLSU}} ·· {{Link Toggle 70SriboSSU}} ·· {{Link Toggle BlackWhiteBackground}}  ·· <br></center></td></tr></table>
The [http://en.wikipedia.org/wiki/ribosome ribosome] is a complex composed of RNA and protein that adds up to several million daltons in size and plays a critical role in the process of decoding the genetic information stored in the genome into protein as outlined in what is now known as [http://sandwalk.blogspot.com/2009/10/ribosome-and-central-dogma-of-molecular.html the Central Dogma of Molecular Biology]. Specifically, the ribosome carries out the process of translation, decoding the genetic information encoded in messenger RNA, one amino acid at a time, into newly synthesized polypeptide chains.
The [http://en.wikipedia.org/wiki/ribosome ribosome] is a complex composed of RNA and protein that adds up to several million daltons in size and plays a critical role in the process of decoding the genetic information stored in the genome into protein as outlined in what is now known as [http://sandwalk.blogspot.com/2009/10/ribosome-and-central-dogma-of-molecular.html the Central Dogma of Molecular Biology]. Specifically, the ribosome carries out the process of translation, decoding the genetic information encoded in messenger RNA, one amino acid at a time, into newly synthesized polypeptide chains.
*'''30S ribosome''' - prokaryote small subunit
*'''40S ribosome''' - eukaryote small subunit
*'''pre-40S ribosome''' - eukaryote small subunit with associated assembly factors
*'''43S ribosome''' - eukaryote preinitiation small subunit containing eIF3, eIF1 and eIF1A
*'''48S ribosome''' - eukaryote small subunit initiation complex containing Met-tRNA
*'''50S ribosome''' - prokaryote large subunit
*'''60S ribosome''' - eukaryote large subunit
*'''pre-60S ribosome''' - eukaryote nucleolar large subunit with associated assembly factors
*'''70S ribosome''' - prokaryote full ribosome containing small and large subunits
*'''80S ribosome''' - eukaryote full ribosome containing small and large subunits
*'''90S pre-ribosome''' - eukaryote an early biogenesis ribosome intermediate containing assembly factors and small nucleolar RNAs.
*'''100S ribosome''' - a dimer of prokaryote full ribosomes


==Nobel Prize Winners and Other Contributors==
==Nobel Prize Winners and Other Contributors==
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==Ribosome Components==
==Ribosome Components==
<br>
·· {{Link Toggle 70SribotRNAs}} ·· {{Link Toggle 70SribomRNA}} ·· {{Link Toggle 70SriborRNA}} ·· {{Link Toggle 70SriboProtein}} ·· {{Link Toggle 70SriboAsitetRNA}} ·· {{Link Toggle 70SriboPsitetRNA}} ·· {{Link Toggle 70SriboEsitetRNA}} ·· {{Link Toggle 70SriboLSU}} ·· {{Link Toggle 70SriboSSU}} ·· {{Link Toggle BlackWhiteBackground}}  ··
The small subunit of the prokaryotic ribosome sediments at 30S<ref>[http://en.wikipedia.org/wiki/Svedberg Svedberg unit] in Wikipedia</ref>. It is composed of a 16S chain of RNA about 1,500 bases long (~500 kDa), plus about 20 protein chains. The proteins in the first small subunit determined range from about 3 kDa to 29 kDa.
The small subunit of the prokaryotic ribosome sediments at 30S<ref>[http://en.wikipedia.org/wiki/Svedberg Svedberg unit] in Wikipedia</ref>. It is composed of a 16S chain of RNA about 1,500 bases long (~500 kDa), plus about 20 protein chains. The proteins in the first small subunit determined range from about 3 kDa to 29 kDa.


The large subunit of the prokaryotic ribosome sediments at 50S. It is composed of two chains of RNA, a 23S chain (~3000 bases long, 946 kDa) and a 5S chain (~120 bases long, 39 kDa). Assembled with the RNA are about 30 protein chains. The proteins in the first large subunit determined range from 6 kDa to 37 kDa.  See also [[Large Ribosomal Subunit of Haloarcula]].
The large subunit of the prokaryotic ribosome sediments at 50S. It is composed of two chains of RNA, a 23S chain (~3000 bases long, 946 kDa) and a 5S chain (~120 bases long, 39 kDa). Assembled with the RNA are about 30 protein chains. The proteins in the first large subunit determined range from 6 kDa to 37 kDa.  See also [[Large Ribosomal Subunit of Haloarcula]].  The large subunit contains several [[Kink-turn motif]]s.
 
The ''mitochindrial ribosome'' or '''mitoribosome''' is smaller than the the cytoplasmic ribosome with a small subunit which sediments at 28S and a large subunit which sediments at 39S.  The whole mitoribosome sediments at 55S.


Other macromolecules in a functioning ribosome include three transfer RNA molecules, messenger RNA, and the nascent protein chain.
Other macromolecules in a functioning ribosome include three transfer RNA molecules, messenger RNA, and the nascent protein chain.
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*<b>Yonath lab original atomic-resolution structures</b><ref>PMID: 11007480</ref><ref>PMID: 11733066</ref>: <em>Thermus thermophilus</em> small ribosomal subunit - [[1fka]], improved in [[1i94]], [[1i95]], [[1i96]], and [[1i97]]. <em>Thermus thermophilus</em> is a [[Extremophiles|thermophilic]] eubacteria. <em>Deinococcus radiodurans</em> large ribosomal subunit - [[1nkw]], later refined to give [[2zjr]]. <em>Deinococcus radiodurans</em> is a mesophilic eubacteria.<br>
*<b>Yonath lab original atomic-resolution structures</b><ref>PMID: 11007480</ref><ref>PMID: 11733066</ref>: <em>Thermus thermophilus</em> small ribosomal subunit - [[1fka]], improved in [[1i94]], [[1i95]], [[1i96]], and [[1i97]]. <em>Thermus thermophilus</em> is a [[Extremophiles|thermophilic]] eubacteria. <em>Deinococcus radiodurans</em> large ribosomal subunit - [[1nkw]], later refined to give [[2zjr]]. <em>Deinococcus radiodurans</em> is a mesophilic eubacteria.<br>


*<b>Ramakrishnan lab original atomic-resolution structures</b><ref>PMID: 11014182</ref><ref>PMID: 11014183</ref>: <em>Thermus thermophilus</em> small ribosomal subunit -[[1fjf]] which was later refined to [[1j5e]]. Related: in complex with the antibiotics streptomycin, spectinomycin, and paromomycin in [[1fjg]]; in complex with tetracycline in [[1hnw]], pactamycin in [[1hnx]], hygromycin B in [[1hnz]].
*<b>Ramakrishnan lab original atomic-resolution structures</b><ref>PMID: 11014182</ref><ref>PMID: 11014183</ref>: <em>Thermus thermophilus</em> small ribosomal subunit in [[1j5e]]. Related: in complex with the antibiotics streptomycin, spectinomycin, and paromomycin in [[1fjg]]; in complex with tetracycline in [[1hnw]], pactamycin in [[1hnx]], hygromycin B in [[1hnz]].
The <em>Thermus thermophilus</em> small ribosomal subunit is composed of a 16S chain of RNA about 1,522 bases long (494 kDa), plus 20 protein chains (S2-S20, THX). The protein chains range from 26 (THX, 3 kDa) to 256 amino acids (S2, 29 kDa).  
The <em>Thermus thermophilus</em> small ribosomal subunit is composed of a 16S chain of RNA about 1,522 bases long (494 kDa), plus 20 protein chains (S2-S20, THX). The protein chains range from 26 (THX, 3 kDa) to 256 amino acids (S2, 29 kDa).  


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*[[Large Ribosomal Subunit of Haloarcula|The Large Ribosomal Subunit]] as solved by the Steitz & Moore labs.<br>
*[[Large Ribosomal Subunit of Haloarcula|The Large Ribosomal Subunit]] as solved by the Steitz & Moore labs.<br>
*[[User:Wayne Decatur/Interactions between Antibiotics and the Ribosome|Interactions between Antibiotics and the Ribosome]]<br>
*[[User:Wayne Decatur/Interactions between Antibiotics and the Ribosome|Interactions between Antibiotics and the Ribosome]]<br>
*[[Large Ribosomal Subunit of Haloarcula]]<br />
*[[User:Wayne_Decatur/Haloarcula Large Ribosomal Subunit With Azithromycin|Azithromycin bound to the Large Ribosomal Subunit of Haloarcula marismortui]]<br>
*[[User:Wayne_Decatur/Haloarcula Large Ribosomal Subunit With Azithromycin|Azithromycin bound to the Large Ribosomal Subunit of Haloarcula marismortui]]<br>
*[[Azithromycin]]<br />
*[[Clarithromycin]]<br />
*[[Doxycycline]]<br />
*[[40S rRNA and proteins and P/E tRNA for eukaryotic ribosome]]<br />
*[[Ribosomal A Site Binding Paromomycin: A Morph]]<br />
*[[Large Ribosomal Subunit of Haloarcula|The Large Ribosomal Subunit]]<br />
*[[Ribosome structure]]<br />
*[[Ribosome structure (Spanish)]]<br />
*[[Ribosome (Czech)]]<br />


==Ribosome 3D structures==


==3D structures of BAG family proteins==
[[Ribosome 3D structures]]


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
==See Also==
 
===30S subunit + RNA===
 
[[2zm6]], [[1n36]], [[1j5e]], [[3oto]] - Tt30S ribosomal subunit+THX+16S RRNA – Thermus thermophiles<br />
[[2vqe]], [[2vqf]], [[2uuc]], 2e5l]], [[2uu9]], [[2uua]], [[2uub]], [[3pyn]], [[3pyq]], [[3pys]], [[3pyu]] - Tt30S ribosomal subunit+16S RRNA+RNA fragment<br />
[[3kc4]] - Ec30S ribosomal subunit - Escherichia coli<br />
[[3i1m]], [[3i1o]], [[3df1]], [[3df3]], [[2vho]], [[2vhp]], [[2avy]], [[2aw7]], [[1pnx]] - Ec30S ribosomal subunit+16S RRNA<br />
[[1i94]], [[1fka]], [[3uxs]], [[3uxt]], [[4dr1]] -  Tt30S ribosomal subunit+16S RRNA<br />
[[4duy]], [[4duz]], [[4dv0]], [[4dv1]], [[4dv2]], [[4dv3]], [[4dv4]], [[4dv5]], [[4dv6]], [[4dv7]] - Tt30S ribosomal subunit+16S RRNA (mutant)<br />
[[4dr4]], [[4b3m]], [[4b3r]], [[4b3s]], [[4b3t]] - Tt30S ribosomal subunit+16S RRNA + mRNA<br />
[[1p87]] - Ec30S ribosomal subunit+16S RRNA – Cryo-EM<br />
[[3bbn]] - s30S ribosomal subunit+16S RRNA – Cryo-EM – spinach<br />
 
=== 30S subunit + chain release factor===
 
[[3mr8]], [[3ms0]] – Tt30S ribosomal subunit+THX+chain release factor 1+P-site tRNA+mRNA+16S RRNA <br />
[[3d5a]] [[3d5c]] - Tt30S ribosomal subunit+THX+chain release factor 1+P-site tRNA+E-site tRNA+mRNA +16S RRNA<br />
[[3zvo]] - Tt30S ribosomal subunit+THX+P-site tRNA Met +mRNA +16S RRNA+chain release factor 3<br />
[[2b64]] - Tt30S ribosomal subunit+THX+P-site tRNA Phe+E-site tRNA Phe+mRNA +16S RRNA+chain release factor 1<br />
[[2b9m]] - Tt30S ribosomal subunit+THX+P-site tRNA Phe+E-site tRNA Phe+mRNA +16S RRNA+chain release factor 2<br />
[[2x9r]], [[2x9t]], [[2wh1]], [[2wh3]] - Tt30S ribosomal subunit+THX+chain release factor 2+P-site tRNA+mRNA +16S RRNA<br />
[[3f1e]], [[3f1g]] - Tt30S ribosomal subunit+THX+chain release factor 2+P-site tRNA+E-site tRNA +16S RRNA<br />
[[4kfh]], [[4kfk]] - Tt30S ribosomal subunit+16S RRNA+ RF-2  + mRNA+ P-site tRNA fMet<br />
 
===30S subunit +tRNA+mRNA===
 
[[2hgi]] - Tt30S ribosomal subunit+16S RRNA+tRNA Phe+tRNA fMet<br />
[[4l6k]], [[4l6m]] - Tt30S ribosomal subunit+16S RRNA+tRNA Phe+tRNA<br />
[[2hgp]] - Tt30S ribosomal subunit+16S RRNA+tRNA Phe+mRNA<br />
[[3t1h]], [[3t1y]] - Tt30S ribosomal subunit+16S RRNA+tRNA Lys +mRNA<br />
[[3tvf]], [[3tvg]], [[3uyd]], [[3uyf]] - Tt30S ribosomal subunit+16S RRNA+tRNA Leu + tRNA fMet + mRNA<br />
[[3zn7]], [[3znd]] - Tt30S ribosomal subunit+16S RRNA+A-site tRNA Ile agmatidine + E-site tRNA Ile agmatidine + mRNA<br />
[[3uz6]], [[3uz7]], [[3uzg]], [[3uzi]] - Tt30S ribosomal subunit+16S RRNA+tRNA Tyr + tRNA fMet + mRNA<br />
[[2i2p]], [[2i2u]] - Ec30S ribosomal subunit+16S RRNA+tRNA Phe+mRNA<br />
[[2hgr]], [[3v6u]], [[3v6v]], [[4ej9]], [[4eja]] - Tt30S ribosomal subunit+16S RRNA+tRNA Phe+tRNA fMet+mRNA<br />
[[1yl4]] – Tt30S ribosomal subunit+ tRNA Phe+16S RRNA+THRS mRNA operator<br />
[[1pns]] - Ec30S ribosomal subunit+ tRNA Phe+16S RRNA+mRNA <br />
[[3j13]] - Ec30S ribosomal subunit+ P-site tRNA +16S RRNA+mRNA – Cryo-EM<br />
[[3j0u]], [[3j0v]], [[3j0x]], [[3j0z]], [[3j10]], [[3j20]] - Ec30S ribosomal subunit+ A-site tRNA + P-site tRNA +16S RRNA+mRNA – Cryo-EM<br />
[[1xnq]], [[1xnr]] - Tt30S ribosomal subunit+THX+mRNA+tRNA anticodon+16S RRNA<br />
[[4gkj]], [[4gkk]] - Tt30S ribosomal subunit +16S RRNA +THX + mRNA + tRNA Met<br />
[[4jv5]], [[4jya]], [[4k0k]], [[4k0l]] - Tt30S ribosomal subunit +16S RRNA +THX + mRNA + ASL-tRNA <br />
 
===30S subunit +A-site tRNA===
 
[[2uxd]], [[2uxc]] -  Tt30S ribosomal subunit+THX+A-site mRNA CGGG+tRNA anticodon+16S RRNA<br />
[[1n32]], [[1n33]] - Tt30S ribosomal subunit+THX+A-site mRNA fragment+tRNA anticodon+16S RRNA<br />
[[1n34]] - Tt30S ribosomal subunit+THX+A-site mRNA fragment +16S RRNA<br />
1xmo]], 1xmq]] - Tt30S ribosomal subunit+THX+A-site mRNA+tRNA anticodon+16S RRNA<br />
[[2uxb]] - Tt30S ribosomal subunit+THX+A-site mRNA GGGU+tRNA anticodon+16S RRNA<br />
 
===30S subunit+P-site tRNA===
 
[[3i8g]] - Tt30S ribosomal subunit+P-site tRNA+mRNA +16S RRNA<br />
[[3i8h]], [[3i9b]], [[3i9d]] - Tt30S ribosomal subunit+THX+P-site tRNA+mRNA +16S RRNA<br />
[[1ibk]] - Tt30S ribosomal subunit+THX+P-site mRNA fragment +16S RRNA<br />
[[2wwl]] - Ec30S ribosomal subunit+Poly-Ala chain+P-site tRNA+mRNA +16S RRNA <br />
[[3i1q]] - Ec30S ribosomal subunit+P-site tRNA hairpin+mRNA <br />
[[3i1s]], [[3i1z]], [[3i21]] - Ec30S ribosomal subunit+P-site tRNA hairpin+mRNA +16S RNA<br />
[[2om7]] – TtRPS2+TtRPS12+TtRPL1+ P-site tRNA+16S RRNA fragment+23S RRNA fragment<br />
 
===30S subunit+A-site tRNA+P-site tRNA===
[[1ibl]], [[1ibm]] - Tt30S ribosomal subunit+THX+A-site mRNA fragment+P-site mRNA fragment+tRNA anticodon+16S RRNA<br />
 
===30S subunit+P-site tRNA+E-site tRNA ===
 
[[2ow8]] - Tt30S ribosomal subunit+THX+P-site tRNA Phe+E-site tRNA+mRNA +16S RRNA<br />
[[2b9o]] - Tt30S ribosomal subunit+THX+P-site tRNA Phe+E-site tRNA Phe+mRNA +16S RRNA<br />
[[2qnh]] -  Tt30S ribosomal subunit+THX+P-site tRNA+E-site tRNA+mRNA +16S RRNA<br />
[[2wdg]], [[2wdh]], [[2wdk]], [[2wdm]] - Tt30S ribosomal subunit+THX+P-site tRNA+E-site tRNA+mRNA +16S RRNA+tRNA Phe<br />
 
===30S subunit+A-site tRNA+P-site tRNA+E-site tRNA===
 
[[2gy9]], [[2gyb]] -  Ec30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA+mRNA +16S RRNA – Cryo-EM<br />
[[1jgo]], [[1jgp]], [[1jgq]], [[1gix]] -  Tt30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA+tRNA Phe+mRNA +16S RRNA<br />
[[4k0p]] - Tt30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA +mRNA +16S RRNA<br />
[[3e1a]], [[3e1c]] -  Ec30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA+mRNA +16S RRNA<br />
 
===30S subunit + antibiotics===
 
[[1i95]], [[1i97]], [[2hhh]], [[2f4v]], [[3oge]], [[3ogy]], [[3ohc]], [[3ohd]], [[3ohy]], [[3oi0]], [[3oi2]], [[3oi4]], [[4dr3]] -  Tt30S ribosomal subunit+16S RRNA+antibiotic<br />
[[1hnx]], [[1hnw]], [[1hnz]], [[1fjg]], [[4aqy]], [[4dr5]], [[4dr6]], [[4dr7]], [[4khp]] - Tt30S ribosomal subunit+16S RRNA+mRNA fragment+antibiotic <br />
[[2qbb]], [[2qb9]], [[1vs5]], [[1vs7]] , [[2qan]], [[2qal]], [[2qou]], [[2qow]], [[2qoy,]] [[2qp0]], [[2z4k]], [[2z4m]], [[3oaq]], [[3oar]], [[3ofa]], [[3ofb]], [[3ofo]], [[3ofp]], [[3ofx]], [[3ofy]], [[3or9]], [[3ora]] - Ec30S ribosomal subunit+16S RRNA+antibiotic<br />
[[4gaq]], [[4gas]] - Ec30S ribosomal subunit+16S RRNA+ mRNA + antibiotic<br />
[[3sfs]] - Ec30S ribosomal subunit+16S RRNA+ mRNA + RF-3 + antibiotic<br />
[[2j00]], [[2j02]] - Tt30S ribosomal subunit+16S RRNA+paromomycin+P-site tRNA fMet+E-site tRNA Phe+mRNA<br />
[[3knl]], [[3knm]], [[3knn]], [[3kno]], [[3knj]], [[3knh]] - Tt30S ribosomal subunit+P-site tRNA+A-site tRNA+E-site tRNA+mRNA +16S RRNA+ antibiotic<br />
[[3uz3]], [[3uz4]] - Tt30S ribosomal subunit+16S RRNA+tRNA Leu + tRNA fMet + mRNA + paromomycin<br />
[[4g5k]], [[4g5m]], [[4g5t]], [[4g5v]] - Tt30S ribosomal subunit+16S RRNA + tRNA fMet + mRNA + antibiotics<br />
[[3uzl]], [[3uzm]] - Tt30S ribosomal subunit+16S RRNA+tRNA Tyr + tRNA fMet + mRNA + paromomycin<br />
 
===30S subunit + ribosome recycling factor===
 
[[2qbd]], [[2qbf]] - Ec30S ribosomal subunit+16S RRNA+ribosome recycling factor<br />
[[3r8n]], [[3r8o]], [[4gd1]], [[4gd2]] - Ec30S ribosomal subunit+16S RRNA+ribosome recycling factor + mRNA + tRNA<br />
[[2qbh]], [[2qbj]] - Ec30S ribosomal subunit+16S RRNA+ribosome recycling factor+gentamicin<br />
[[2v46]], [[2v48]] -  Tt30S ribosomal subunit+16S RRNA+ribosome recycling factor+P-site tRNA Phe+mRNA+tRNA fMet<br />
 
===30S subunit + elongation factor===
 
[[2wri]], [[2wrk]] - Tt30S ribosomal subunit+THX+P-site tRNA+mRNA +16S RRNA+elongation factor G<br />
[[2wrn]], [[2wrq]] - Tt30S ribosomal subunit+THX+A-site tRNA+mRNA +16S RRNA+elongation factor TU-4<br />
[[3fic]] - Tt30S ribosomal subunit+THX+A-site tRNA+P-site tRNA+E-site tRNA+mRNA codon+16S RRNA+elongation factor TU-A<br />
[[4abr]] - Tt30S ribosomal subunit+THX + E/P-site tRNA fMet +mRNA codon+16S RRNA+elongation factor TU<br />
[[2y0u]], [[2y0w]], [[2y0y]], [[2y12]], [[2y10]], [[2y18]], [[2y14]], [[2y16]] - Tt30S ribosomal subunit+THX+A-site tRNA+E-site tRNA+mRNA codon+16S RRNA+elongation factor TU<br />
[[3fih]] - Ec30S ribosomal subunit+A-site tRNA Phe+P-site tRNA+mRNA +16S RRNA+elongation factor TU<br />
[[3izv]] - Ec30S ribosomal subunit+A/T-site tRNA Phe +16S RRNA+elongation factor TU<br />
[[3j18]] - Ec30S ribosomal subunit+A/T-site tRNA Phe +16S RRNA+ mRNA + SSRA-binding protein + formyl-Met specific initiator tRNA + elongation factor G – Cryo-EM<br />
[[3izw]] - Ec30S ribosomal subunit+A-site tRNA Phe +mRNA +16S RRNA+elongation factor TU<br />
[[3huw]], [[3huy]] - Tt30S ribosomal subunit+THX+tRNA-Met+mRNA +16S RRNA+elongation factor P<br />
[[4b8f]], [[4b8h]] - Tt30S ribosomal subunit+THX+RNA+mRNA +16S RRNA+elongation factor G<br />
[[4btc]], [[4kdg]], [[4kdj]] - Tt30S ribosomal subunit+THX+RNA +16S RRNA+elongation factor G<br />
[[4juw]] - Tt30S ribosomal subunit+THX+ tRNA Phe +16S RRNA + mRNA +elongation factor G<br />
[[4kbt]], [[4kbv]], [[4kcy]], [[4kd0]], [[4kd8]], [[4kda]] - Tt30S ribosomal subunit+THX+ tRNA Met +16S RRNA + mRNA + viomycin + elongation factor G<br />
[[4kiy]], [[4kj0]], [[4kj2]], [[4kj4]], [[4kj6]], [[4kj8]], [[4kja]], [[4kjc]] - Ec30S ribosomal subunit +16S RRNA + viomycin + elongation factor G<br />
 
===30S subunit + translation initiation factor===
 
[[1hr0]] - Tt30S ribosomal subunit+THX+IF+16S RRNA<br />
[[1i96]] -  Tt30S ribosomal subunit+THX+IF3+16S RRNA<br />
 
===30S subunit + various proteins===
 
[[3kiq]], [[3kis]], [[3kiu]], [[3kix]] - Tt30S ribosomal subunit+toxin RelE+16S RRNA<br />
[[2xfz]], [[2xg1]] - Tt30S ribosomal subunit+colicin-E3 fragment+16S RRNA+mRNA+E-site tRNA+THX<br />
[[1voq]], [[1vos]] , [[1vov]], [[1vox]], [[1voz]] - Ec30S ribosomal subunit+protein Y+16S RRNA<br />
[[3j36]] - Ec30S ribosomal subunit+ tetracycline resistance protein +16S RRNA + mRNA + P-tRNA – Cryo-EM<br />
[[1x18]] – TtRPS2+TtRPS7+TtRPS11+TtRPS18+GTP-binding protein ERA+RNA fragments<br />
[[4dh9]], [[4dhb]] - Tt30S ribosomal subunit +16S RRNA+mRNA+P-site tRNA fMet +THX + YAEJ<br />
[[3v22]], [[3v24]], [[3v26]], [[3v28]] - Tt30S ribosomal subunit +16S RRNA +THX + modulation factor<br />
[[3v2c]], [[3v2e]] - Tt30S ribosomal subunit +16S RRNA +THX + ribosome-associated inhibitor<br />
[[3j00]] – EcRPS2 + 16S RRNA + FTSQ + apolipoprotein A-I<br />
[[2ykr]] - EcRPS2 + 16S RRNA + GMPPNP + GTPase RSGA<br />
[[4a2i]] - EcRPS2 + 16S RRNA + GTPase RSGA – Cryo EM<br />
[[3uoq]] - EcRPS2 + 16S RRNA + mRNA + peptide chain release factor<br />
[[4adv]] - EcRPS2 + 16S RRNA + methyltransferase – Cryo EM<br />
 
===40S ribosomal subunit===
 
[[3jyv]] - Tl40S ribosomal subunit+RACK1+S19E+P-site tRNA – Thermomyces lanuginosus<br />
[[2xzm]], [[2xzn]] - Tet40S ribosomal subunit+RACK1 – Tetrahymena thermophila<br />
[[1s1h]] - y40S ribosomal subunit+18S RRNA+elongation factor 2 – Cryo-EM – yeast<br />
[[3izb]] - y40S ribosomal subunit+ RACK1 – Cryo-EM<br />
[[3o2z]], [[3o30]] - y40S ribosomal subunit+ RACK1<br />
[[3u5c]], [[3u5g]] - y40S ribosomal subunit+ RACK1 + suppressor protein SMT1<br />
[[3iz6]] - w40S ribosomal subunit+RACK1 – wheat<br />
[[3j38]] - Dm40S ribosomal subunit + EF-2 + guanine nucleotide-binding protein – Drosophila melanogaster – Cryo-EM<br />
[[3j3a]] - h40S ribosomal subunit + EF-2 + guanine nucleotide-binding protein – human – Cryo-EM<br />
[[4kzx]] - r40S ribosomal subunit+ RACK1 + EIF1 – rabbit – Cryo-EM<br />
[[4kzy]] - r40S ribosomal subunit+ RACK1 + EIF1 + EIF1A – Cryo-EM<br />
[[4kzz]] - r40S ribosomal subunit+ RACK1 + EIF1A + initiator tRNA – Cryo-EM<br />
[[2zkq]] – d40S ribosomal subunit+RACK1+RRNA fragment – dog - Cryo-EM<br />
[[3zey]] - Tb40S ribosomal subunit – Trypanosoma brucei – Cryo-EM<br />
[[4bpe]], [[4bpn]], [[4bpo]], [[4bpp]] - r40S ribosomal subunit+ 18SRRNA + EIF1 + EIF1A <br />
 
===50S subunit+RNA===
 
[[2x9s]], [[2x9u]], [[3kni]], [[3knk]], [[3knm]], [[3kno]], 3hux]], 3huz]], [[2wdi]], [[2wdj]] [[2wdl]] [[1vsp]], [[2v47]] , [[2v49]], [[1vsa]], [[3pyo]], [[3pyr]], [[3pyt]], [[3pyv]], [[3v6w]], [[3v6x]], [[3zne]], [[4btd]], [[4ejb]], [[4ejc]], [[4k0m]], [[4k0q]], [[2wrj]], [[2wrl]], [[2wro]], [[2wrr]], [[2wh2]], [[2wh4]], [[2hgj]],  [[2hgq]], [[2hgu]],[[2j01]], [[2j03]], [[1yl3]],  [[3i8i]], [[3f1f]], [[3f1h]], [[2b66]], [[2b9n]], [[2b9p]], [[1giy]], [[2xqe]], [[2y0v]], [[2y0x]], [[2y0z]], [[2y11]], [[2y13]], [[2y15]], [[2y17]], [[2y19]], [[3zvp]], [[4abs]], [[4b8g]], [[4b8i]], [[4jux]], [[4kbu]], [[4kbw]], [[4kcz]], [[4kd2]], [[4kd9]], [[4kdb]], [[4kdh]], [[4kdk]], [[4kfi]], [[4kfl]] -  Tt50S subunit+5S RRNA+23S RRNA <br />
[[2xg0]], [[2xg2]], [[3kir]], [[3kit]], [[3kiw]], [[3kiy]] – Tt50S subunit+RNA fragments<br />
[[3fin]], [[2xtg]], [[2xux]] - Tt50S subunit+5S RRNA+23S RRNA – Cryo-EM<br />
[[2wwq]] – Ec 50S subunit+5S RRNA+23S RRNA+mRNA+P-site tRNA <br />
[[3i1n]], [[3i1p]], [[3i1r]], [[3i1t]], [[3i20]], [[3i22]], [[3e1b]], [[3e1d]], [[3df2]], [[3df4]], [[2vhn]], [[2qov]], [[2qox]], [[2i2t]], [[2i2v]], [[1vs6]], [[1vs8]], [[2aw4]], [[2awb]], [[3ofd]], [[3og0]], [[3oas]], [[3oat]], [[3uos]], [[3r8s]], [[3r8t]], [[3j37]], [[4kix]], [[4kiz]], [[4kj1]], [[4kj3]], [[4kj5]], [[4kj7]], [[4kj9]], [[4kjb]] - Ec50S subunit+5S RRNA+23S RRNA <br />
[[3fik]], [[2gya]], [[2gyc]], [[1p85]], [[1p86]], [[3izt]], [[3izu]], [[3j0t]], [[3j0w]], [[3j0y]], [[3j11]], [[3j12]], [[3j14]], [[3j19]] -  Ec50S subunit+5S RRNA+23S RRNA – Cryo-EM<br />
[[3kcr]] - Ec50S subunit+5S RRNA+23S RRNA+preprotein translocase<br />
[[3bbo]] -  s50S subunit+5S RRNA+23S RRNA+4.8S RRNA – Cryo-EM <br />
[[2zjq]], [[2zjr]], [[1nkw]] - Dr50S subunit+5S RRNA+23S RRNA – Deinococcus radiodurans<br />
[[2qa4]], [[3cc2]], [[1s72]], [[4hub]], [[1kqs, 1qvg, [[1jj2, [[1ffk  -  Hm50S subunit+5S RRNA+23S RRNA – Haloarcula marismortui<br />
[[3cc7]], [[3cce]], [[3ccj]], [[3ccl]], [[3ccm]], [[3ccq]], [[3ccr]], [[3ccs]], [[3ccu]], [[3ccv]] -  Hm50S subunit+5S RRNA+23S RRNA (mutant) <br />
[[1yj9]] - Hm50S subunit (mutant)+5S RRNA+23S RRNA <br />
[[1qvf]]- Hm50S subunit+5S RRNA+23S RRNA + deacylated tRNA minihelix<br />
[[1q86]] - Hm50S subunit+5S RRNA+23S RRNA+CCA-Phe-caproic acid-biotin<br />
[[3cma]], [[3cme]], [[1vq8]], [[1vq9]], [[1m90]] - Hm50S subunit+5S RRNA+23S RRNA+CCA+CCA-Phe-CAP-BIO<br />
[[1vq4]], [[1vq5]], [[1vq7]], [[1vql]], [[1vqm]], [[1vqp]] – Hm50S subunit+5S RRNA+23S RRNA+transition state analog<br />
[[1vq6]], [[1vqk]], [[1vqn]] – Hm50S subunit+5S RRNA+23S RRNA+ c-hpmn+CCA-Phe-caproic acid-biotin<br />
[[1vqo]] – Hm50S subunit+5S RRNA+23S RRNA+ CCPMN<br />
[[3iy9]] – 50S subunit – Leishmania taretolae<br />
[[2ftc]] – 50S subunit+5S RRNA+23S RRNA – bovine - Cryo_EM<br />
[[3j21]] –  50S subunit + P0 + LX – Pyrococcus furiosus – Cryo EM<br />
[[3j3v]], [[3j3w]] - 50S subunit+5S RRNA+23S RRNA – Bacillus subtilis<br />
 
=== 50S subunit + antibiotics===
 
[[3dll]], [[2zjp]], [[3cf5]], [[1xbp]], [[1sm1]], [[1nwx]], [[1nwy]], [[3pio]], [[3pip]] - Dr50S subunit+5S RRNA+23S RRNA+general stress protein Ctc+ antibiotic<br />
[[4io9]], [[4ioa]], [[4ioc]] - Dr50S subunit+5S RRNA+23S RRNA+ antibiotics<br />
[[2qba]], [[2qbc]], [[4gar]], [[4gau]], [[2qam, [[2qao, [[2qoz, [[2qp1]], [[3ofc]], [[3ofz]], [[3ofq]], [[3ofr]], [[1vt2]], [[3orb]], [[4l6j]], [[4l6l]]  - Ec50S subunit+5S RRNA+23S RRNA+ antibiotics<br />
[[3i55,]] [[3i56]] , [[3g4s]], [[3g4e]], [[3g71]], [[2qex]], [[3cc4]], [[3cd6]], [[1yhq]], [[1yi2]], [[1yij]], [[1yjn]], [[1yjw]], [[2otj]], [[2otl]], [[1yit]], [[1k73]], [[1kc8]], [[1k8a]], [[1k9m]], [[1kd1]], [[1m1k]], [[3cpw]], [[1yit]], [[1q7y]], [[1q81]], [[1q82]], [[1n8r]], [[1nji]], [[3cxc]] - Hm50S subunit+5S RRNA+23S RRNA + antibiotics<br />
[[3oh5]], [[3oh7]], [[3ohj]], [[3ohk]], [[3ohz]], [[3oi1]], [[3oi3]], [[3oi5]] - Tt50S subunit+5S RRNA+23S RRNA+antibiotic <br />
 
=== 60S subunit===
 
[[3jyw]] -  60S subunit – Thermomyces lanuginosus – Cryo-EM<br />
[[1s1i]], [[1s1h]] - y60S ribosomal subunit+ 5.8S RRNA+ 5S RRNA – Cryo-EM <br />
[[3izs]] - y60S subunit – Cryo-EM<br />
[[3u5e]], [[3u5i]] - y60S subunit <br />
[[3o58]], [[3o5h]] - y60S ribosomal subunit+ 5.8S RRNA+ 5S RRNA + 25S RRNA<br />
[[3izr]], [[3izt]], [[3izu]], [[3izs]] - w60S subunit <br />
[[3j39]] – Dm60S subunit – Cryo-EM<br />
[[3j3b]] – h60S subunit – Cryo-EM<br />
[[4a17]], [[4a1a]], [[4a1c]], [[4a1e]] - Tet60S ribosomal subunit + 5S RRNA + 5.8S RRNA <br />
[[3zf7]] - Tb60S subunit - Cryo EM<br />
 
=== large + small ribosomal subunit===
 
[[1ml5]] - Ec50S ribosomal subunit+30S ribosomal subunit+THX+chain release factor 2+P-site tRNA+tRNA Phe+mRNA fragment+23S RRNA+5S RRNA+16S RRNA – Cryo-EM<br />
[[2zkr]] -  d60S ribosomal subunit+30S ribosomal subunit+28S RRNA+5.8S RRNA – Cryo-EM <br />
[[3j0l]] - r60S ribosomal subunit+40S ribosomal subunit+RRNA fragments+ mRNA fragments – Cryo-EM <br />
[[3j0o]], [[3j0p]], [[3j0q]] - r60S ribosomal subunit+40S ribosomal subunit+RRNA fragments+ mRNA fragments + tRNA – Cryo-EM<br />
 
=== 50S subunit + ribosome releasing factor (RRF)===
 
[[2qbe]], [[2qbg]], [[2qbi]], [[2qbk]], [[2z4l]], [[2z4n]] - Ec50S subunit+5S RRNA+23S RRNA+RRF<br />
[[2rdo]] - Ec50S subunit+5S RRNA+23S RRNA+EF-G+RRF – Cryo-EM<br />
[[3j0d]] - Tt50S subunit+5S RRNA+23S RRNA+RRF – Cryo-EM<br />
 
=== 50S subunit + various proteins===
 
[[2vhm]] - Ec50S subunit+5S RRNA+23S RRNA+PDF C-terminal helix<br />
[[2j28]] - Ec50S subunit+5S RRNA+23S RRNA+signal recognition particle – Cryo-EM<br />
[[1vor]], [[1vou]], [[1vow]], [[1voy]], [[1vp0]], [[1pnu]], [[1pny]] - Ec50S subunit+5S RRNA+23S RRNA+general stress protein Ctc<br />
[[3j01]] - Ec 50S subunit+5S RRNA+23S RRNA + SECYE – Cryo-EM<br />
[[w2b]] - Hm50S subunit+5S RRNA+23S RRNA+trigger factor N-terminal<br />


===60S subunit + various proteins===
[[4a18]], [[4a19]], [[4a1b]], [[4a1d]] - Tet60S subunit+ 26S RRNA+ translation initiation factor 6 <br />
[[3izs]] – y60S subunit + P0 + P1 + P2 - Cryo EM<br />
[[3u5i]] – y60S subunit + P0<br />
[[4b6a]] – y60S subunit + P0 + P1 + P2 + ARX1 - Cryo EM<br />
[[3o5h]] – y60S subunit + 5S RRNA + 5.8S RRNA + 25S RRNA + P0<br />
[[3j39]] – Dm60S subunit + P0 – Drosophila melanogaster - Cryo EM<br />
[[3j3b]] – h60S subunit + P0 + P1 + P2 – human - Cryo EM<br />
==See Also==
* [[Nobel Prizes for 3D Molecular Structure]]
* [[Nobel Prizes for 3D Molecular Structure]]
* [[Highest impact structures]] of all time
* [[Highest impact structures]] of all time
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* [[DNA Replication, Transcription and Translation]]
* [[DNA Replication, Transcription and Translation]]
* [[tRNA]]
* [[tRNA]]
* [[Large Ribosomal Subunit of Haloarcula|The Large Ribosomal Subunit]]
* [[LepA|Escherichia coli LepA, the ribosomal back translocase]]
* [[LepA|Escherichia coli LepA, the ribosomal back translocase]]
* [[Extremophiles]]
* [[Extremophiles]]
*[[RNA]]
* [[RNA]]
* [[Ribozyme]]
* [[Ribozyme]]
* For Spanish see [[Ribosoma 70S]]


==References==
==References==
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[[Category:Topic Page]]
[[Category:Topic Page]]
[[Category:Translation]]
[[Category:Translation]]
[[Category:Ribosome]]
[[Category: BioMolViz]]
[[Category: Macromolecular Assemblies]]

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Wayne Decatur, Eric Martz, Eran Hodis, Jaime Prilusky, David Canner, Alexander Berchansky, Michal Harel, Joel L. Sussman, Margaret Franzen
Retrieved from "https://proteopedia.openfox.io/w/Ribosome"