Rho GTPase activating protein: Difference between revisions
Michal Harel (talk | contribs) No edit summary |
Michal Harel (talk | contribs) No edit summary |
||
| (9 intermediate revisions by the same user not shown) | |||
| Line 3: | Line 3: | ||
== Function == | == Function == | ||
'''Rho GTPase activating protein''' (RhoGAP) are one of the main classes of Rho GTPase regulators that are crucial in cell cytoskeletal organization, growth, differentiation, neuronal development and synaptic functions<ref>PMID:12480336</ref>,<ref>PMID:17222083</ref>. RhoGAPs contain a RhoGAP domain. | '''Rho GTPase activating protein''' (RhoGAP) are one of the main classes of Rho GTPase regulators that are crucial in cell cytoskeletal organization, growth, differentiation, neuronal development and synaptic functions<ref>PMID:12480336</ref>,<ref>PMID:17222083</ref>. RhoGAPs contain a RhoGAP domain. | ||
*'''RhoGAP7''' activates the small GTPases RHOA, RHOB, RHOC and CDC42. | |||
*'''RhoGAP9''' regulates adhesion of hematopoietic cells to the extracellular matrix. | |||
*'''RhoGAP11''' causes cell-cycle arrest and apoptosis in response to DNA damage. | |||
*'''RhoGAP12''' may be involved in suppressing tumor formation. | |||
*'''RhoGAP21''' involved in cell adhesion, migration, Golgi regulation, cell trafficking and insulin secretion<ref>PMID:29856495</ref>. | |||
*'''RhoGAP21''' involved in cell adhesion, migration, Golgi regulation, cell trafficking and insulin secretion<ref>PMID:29856495</ref>. | |||
*'''RhoGAP35''' involved in cell adhesion, migration and invasion<ref>PMID:35758029</ref>. | |||
== Relevance == | == Relevance == | ||
RhoGAPs are present in altered abundance in a variety of human cancers and may serve as targets for cancer therapy<ref>PMID:16918449</ref>. | RhoGAPs are present in altered abundance in a variety of human cancers and may serve as targets for cancer therapy<ref>PMID:16918449</ref>,<ref>PMID:34365932</ref>. RhoGAP10 variants may be associated with schizophrenia<ref>PMID:32699248</ref>. | ||
== Structural highlights == | == Structural highlights == | ||