Rho GTPase activating protein: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman, Alexander Berchansky

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-<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
+<StructureSection load='' size='350' side='right' caption='Human RhoGAP 1 (magenta) complex with RhoA (blue), GDP, MgF3 and Mg+2 ions (PDB code [[1ow3]])' scene='75/750307/Cv1/1' pspeed='8'>
+__TOC__
 == Function ==
-'''Rho GTPase acivating protein''' (RhoGAP) are one of the main classes of Rho GTPase regulators that are crucial in cell cytoskeletal organization, growth, differentiation, neuronal development and synaptic functions<ref>PMID:12480336</ref>.  RhoGAPs contain a RhoGAP domain.
+'''Rho GTPase activating protein''' (RhoGAP) are one of the main classes of Rho GTPase regulators that are crucial in cell cytoskeletal organization, growth, differentiation, neuronal development and synaptic functions<ref>PMID:12480336</ref>,<ref>PMID:17222083</ref>.  RhoGAPs contain a RhoGAP domain.
+*'''RhoGAP7''' activates the small GTPases RHOA, RHOB, RHOC and CDC42.
+*'''RhoGAP9''' regulates adhesion of hematopoietic cells to the extracellular matrix.
+*'''RhoGAP11''' causes cell-cycle arrest and apoptosis in response to DNA damage.
+*'''RhoGAP12''' may be involved in suppressing tumor formation.
+*'''RhoGAP21''' involved in cell adhesion, migration, Golgi regulation, cell trafficking and insulin secretion<ref>PMID:29856495</ref>.
+*'''RhoGAP21''' involved in cell adhesion, migration, Golgi regulation, cell trafficking and insulin secretion<ref>PMID:29856495</ref>.
+*'''RhoGAP35''' involved in cell adhesion, migration and invasion<ref>PMID:35758029</ref>.
 == Relevance ==
-RhoGAPs are present in altered abundance in a variety of human cancers and may serve as targets for cancer therapy<ref>PMID:16918449</ref>.
+RhoGAPs are present in altered abundance in a variety of human cancers and may serve as targets for cancer therapy<ref>PMID:16918449</ref>,<ref>PMID:34365932</ref>.  RhoGAP10 variants may be associated with schizophrenia<ref>PMID:32699248</ref>.
 == Structural highlights ==
+The <scene name='75/750307/Cv/6'>active site of RhoGAP</scene> contains a <scene name='75/750307/Cv/7'>catalytic arginine</scene> and GDP<ref>PMID:11927263</ref>. Water molecules are shown as red spheres. <scene name='75/750307/Cv/8'>Mg/MgF3 coordination site</scene>.
+==3D structures of Rho GTPase activating protein==
+[[Rho GTPase activating protein 3D structures]]
 </StructureSection>
-==3D structures of Rho GTPase activating protein==
-[[4u3k]] - yRhoGAP 1 RhoGAP domain - yeast<br />
-[[1ow3]] - hRhoGAP 1 residues 198-439 + RhoA + GDP - human<br />
-[[5irc]] - RhoGAP 35 + RhoA - rat<br />
-[[4rtt]], [[4rug]], [[2gnc]] - hRhoGAP 2 SLIT-ROBO SH3 domain <br />
-[[2dl8]] - hRhoGAP 2 SLIT-ROBO SH3 domain - NMR<br />
-[[2epd]] - hRhoGAP 4 SH3 domain - NMR<br />
-[[2ee4]] , [[2ee5]] - hRhoGAP 5 (mutant) RhoGAP domain - NMR<br />
-[[3kuq]] - hRhoGAP 7 RhoGAP domain<br />
-[[2kap]], [[2dky]] - hRhoGAP 7 SAM domain - NMR<br />
-[[2p0d]], [[2p0f]], [[2p0h]] - hRhoGAP 9 pleckstrin homology domain + phosphoinositide<br />
-[[2mio]] - hRhoGAP 10 SH3 domain - NMR<br />
-[[2j59]] - hRhoGAP 10 ARF-binding domain + ADP-ribosylation factor<br />
-[[3eap]] - hRhoGAP 11A RhoGAP domain<br />
-[[3byi]] - RhoGAP 15 residues 262-473<br />
-[[3msx]] - hRhoGAP 20 RhoGAP domain + RhoA<br />
-[[2yuy]] - hRhoGAP 21 PDZ domain - NMR<br />
-[[2dhj]] - hRhoGAP 21 pleckstrin homology domain - NMR<br />
-[[3pp2]] - hRhoGAP 27 pleckstrin homology domain<br />
-[[4wpc]] - yRhoGAP 1 F-BARR domain + inositol phosphate<br />
-[[1grn]] - hRhoGAP C-terminal + GTP-binding protein<br />
 == References ==
 <references/>
+[[Category:Topic Page]]