C-Myc: Difference between revisions
David Canner (talk | contribs) No edit summary |
Michal Harel (talk | contribs) No edit summary |
||
| (19 intermediate revisions by 4 users not shown) | |||
| Line 1: | Line 1: | ||
< | <StructureSection load='2A93-custom.pdb' size='350' side='right' scene='C-Myc/Custom/2' caption='c-Myc [[2a93]] is a [http://en.wikipedia.org/wiki/DNA-binding_protein DNA binding protein]'> | ||
== Overview == | == Overview == | ||
---- | ---- | ||
The c-Myc [http://en.wikipedia.org/wiki/Oncogene oncogene] encodes a [http://en.wikipedia.org/wiki/Transcription_factor transcription factor], c-Myc protein, which is involved in the regulation of the [http://en.wikipedia.org/wiki/Cell_cycle cell cycle]. C-Myc belongs to the [http://en.wikipedia.org/wiki/C-myc Myc] family of proteins including B-Myc, L-Myc, N-Myc, and s-Myc. c-Myc is a [http://en.wikipedia.org/wiki/Basic_helix-loop-helix_leucine_zipper_transcription_factors b-HLH-LZ] (basic helix-loop-helix-leucine zipper) protein that must form a [http://en.wikipedia.org/wiki/Heterodimer heterodimer] with another b-HLH-LZ protein, [http://en.wikipedia.org/wiki/MAX_(gene) Max], in order to bind DNA and activate [http://en.wikipedia.org/wiki/Transcription_(genetics) transcription]. | The '''c-Myc''' [http://en.wikipedia.org/wiki/Oncogene oncogene] encodes a [http://en.wikipedia.org/wiki/Transcription_factor transcription factor], c-Myc protein, which is involved in the regulation of the [http://en.wikipedia.org/wiki/Cell_cycle cell cycle]. C-Myc belongs to the [http://en.wikipedia.org/wiki/C-myc Myc] family of proteins including B-Myc, L-Myc, N-Myc, and s-Myc. c-Myc is a [http://en.wikipedia.org/wiki/Basic_helix-loop-helix_leucine_zipper_transcription_factors b-HLH-LZ] (basic helix-loop-helix-leucine zipper) protein that must form a [http://en.wikipedia.org/wiki/Heterodimer heterodimer] with another b-HLH-LZ protein, [http://en.wikipedia.org/wiki/MAX_(gene) Max], in order to bind DNA and activate [http://en.wikipedia.org/wiki/Transcription_(genetics) transcription]. | ||
Mutations in myc proteins or overexpression of their encoding genes have been linked to several forms of cancer, among these are lymphoma, myeloma, liver, lung, and breast cancer. | Mutations in myc proteins or overexpression of their encoding genes have been linked to several forms of cancer, among these are lymphoma, myeloma, liver, lung, and breast cancer. See<br /> | ||
[[Kwon sandbox]]<br /> | |||
[[Transcription and RNA Processing]]<br /> | |||
[[Proteins involved in cancer]]<br /> | |||
[[Oncogenes & Tumor Suppressor Genes]]. | |||
[[Category:Topic Page]] | |||
| Line 34: | Line 38: | ||
==Experiments with C-myc== | ==Experiments with C-myc== | ||
An experiment was done to see if mice could survive embryonic development without the C-myc gene. This was done by using a mutation to make the C-myc allele null at the protein level. They gave some of the embryos one correct copy of the allele and others no correct copy. The homozygous mice (two null C-myc alleles), died between 9.5 and 10.5 days of gestation. The mice also were smaller and had many health problems. This showed that C-myc is vital to the development of embryos of organisms. | An experiment was done to see if mice could survive embryonic development without the C-myc gene. This was done by using a mutation to make the C-myc allele null at the protein level. They gave some of the embryos one correct copy of the allele and others no correct copy. The homozygous mice (two null C-myc alleles), died between 9.5 and 10.5 days of gestation. The mice also were smaller and had many health problems. This showed that C-myc is vital to the development of embryos of organisms. | ||
</StructureSection> | |||
==3D structures of C-myc== | |||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | |||
[[2a93]] – Cmyc-Max leucine zipper – synthetic – NMR<br /> | |||
[[2ap2]] – sCmyc + antibody<br /> | |||
[[5i4z]] - hCmyc bHLHZ domain residues 348-439 - human<br /> | |||
[[7c36]] - hCmyc residues 62-223 - NMR<br /> | |||
[[5i50]] - hCmyc bHLHZ domain + DNA<br /> | |||
[[6g6j]], [[6g6k]], [[6g6l]] – hCmyc + hMax<br /> | |||
[[1nkp]] – hCmyc + hMax + DNA <br /> | |||
[[1mv0]] – hCmyc residues 55-68 + box-dependent-interacting protein residues 513-593 - NMR | |||
[[8ots]], [[8ott]] - hCmyc bHLHZ domain 368-420 complx with nucleosome – Cryo EM | |||
==Additional Resources== | ==Additional Resources== | ||
For additional information, see: [[Cancer]] | For additional information, see: [[Cancer]] <br /> | ||
For additional information, see: [[Oncogenes]] | For additional information, see: [[Oncogenes]] <br /> | ||
For additional information, see: [[Transcription and RNA Processing]] | |||
<br /> | |||
<br /> | <br /> | ||