3a3n: Difference between revisions

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==Crystal structure of complex between SA-subtilisin and Tk-propeptide with deletion of the two C-terminal residues==
==Crystal structure of complex between SA-subtilisin and Tk-propeptide with deletion of the two C-terminal residues==
<StructureSection load='3a3n' size='340' side='right' caption='[[3a3n]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='3a3n' size='340' side='right'caption='[[3a3n]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3a3n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"thermococcus_kodakaraensis"_atomi_et_al._2004 "thermococcus kodakaraensis" atomi et al. 2004]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A3N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3A3N FirstGlance]. <br>
<table><tr><td colspan='2'>[[3a3n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermococcus_kodakarensis Thermococcus kodakarensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A3N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3A3N FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2z30|2z30]], [[3a3o|3a3o]], [[3a3p|3a3p]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3a3n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a3n OCA], [http://pdbe.org/3a3n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3a3n RCSB], [http://www.ebi.ac.uk/pdbsum/3a3n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3a3n ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3a3n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a3n OCA], [https://pdbe.org/3a3n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3a3n RCSB], [https://www.ebi.ac.uk/pdbsum/3a3n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3a3n ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TKSU_THEKO TKSU_THEKO]] Has a broad substrate specificity with a slight preference to large hydrophobic amino acid residues at the P1 position.  
[https://www.uniprot.org/uniprot/TKSU_THEKO TKSU_THEKO] Has a broad substrate specificity with a slight preference to large hydrophobic amino acid residues at the P1 position.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a3/3a3n_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a3/3a3n_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
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==See Also==
==See Also==
*[[Subtilisin|Subtilisin]]
*[[Subtilisin 3D structures|Subtilisin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Thermococcus kodakaraensis atomi et al. 2004]]
[[Category: Large Structures]]
[[Category: Kanaya, S]]
[[Category: Thermococcus kodakarensis]]
[[Category: Koga, Y]]
[[Category: Kanaya S]]
[[Category: Matsumura, H]]
[[Category: Koga Y]]
[[Category: Takano, K]]
[[Category: Matsumura H]]
[[Category: Tanaka, S]]
[[Category: Takano K]]
[[Category: Hydrolase]]
[[Category: Tanaka S]]
[[Category: Propeptide]]
[[Category: Protease]]
[[Category: Secreted]]
[[Category: Serine protease]]
[[Category: Subtilisin]]
[[Category: Thermococcus kodakaraensis]]
[[Category: Zymogen]]

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