5uk2: Difference between revisions

<StructureSection load='5uk2' size='340' side='right'caption='[[5uk2]], [[Resolution|resolution]] 4.80&Aring;' scene=''>

<table><tr><td colspan='2'>[[5uk2]] is a 9 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/solomon_islands/03/2006(h1n1)) Influenza a virus (a/solomon islands/03/2006(h1n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UK2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UK2 FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>

<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ujz|5ujz]], [[5uk0|5uk0]], [[5uk1|5uk1]]</td></tr>

<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=464623 Influenza A virus (A/Solomon Islands/03/2006(H1N1))])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uk2 OCA], [http://pdbe.org/5uk2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uk2 RCSB], [http://www.ebi.ac.uk/pdbsum/5uk2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uk2 ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/A7UPX0_9INFA A7UPX0_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[RuleBase:RU003324][SAAS:SAAS00145386]  

</StructureSection>

[[Category: Human]]

[[Category: Caradonna, T]]

[[Category: Grigorieff, N]]

[[Category: Harrison, S C]]

[[Category: Jenni, S]]

[[Category: Liu, Y]]

[[Category: Pan, J]]

[[Category: Raymond, D D]]

[[Category: Schmidt, A G]]

[[Category: Viral protein-immune system complex]]