3hha: Difference between revisions

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-[[Image:3hha.png|left|200px]]
-{{STRUCTURE_3hha|  PDB=3hha  |  SCENE=  }}
+==Crystal structure of cathepsin L in complex with AZ12878478==
+<StructureSection load='3hha' size='340' side='right'caption='[[3hha]], [[Resolution|resolution]] 1.27&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3hha]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HHA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HHA FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.27&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NOW:NALPHA-[(3-TERT-BUTYL-1-METHYL-1H-PYRAZOL-5-YL)CARBONYL]-N-[(2Z)-2-IMINOETHYL]-3-METHYL-L-PHENYLALANINAMIDE'>NOW</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hha FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hha OCA], [https://pdbe.org/3hha PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hha RCSB], [https://www.ebi.ac.uk/pdbsum/3hha PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hha ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CATL1_HUMAN CATL1_HUMAN] Important for the overall degradation of proteins in lysosomes.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hh/3hha_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hha ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+A series of potent Cathepsin L inhibitors with good selectivity with respect to other cysteine Cathepsins is described and SAR is discussed with reference to the crystal structure of a protein-ligand complex.
-===Crystal structure of cathepsin L in complex with AZ12878478===
+Dipeptidyl nitrile inhibitors of Cathepsin L.,Asaad N, Bethel PA, Coulson MD, Dawson JE, Ford SJ, Gerhardt S, Grist M, Hamlin GA, James MJ, Jones EV, Karoutchi GI, Kenny PW, Morley AD, Oldham K, Rankine N, Ryan D, Wells SL, Wood L, Augustin M, Krapp S, Simader H, Steinbacher S Bioorg Med Chem Lett. 2009 Aug 1;19(15):4280-3. Epub 2009 May 27. PMID:19515558<ref>PMID:19515558</ref>
-{{ABSTRACT_PUBMED_19515558}}
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-==About this Structure==
+<div class="pdbe-citations 3hha" style="background-color:#fffaf0;"></div>
-[[3hha]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HHA OCA].
 ==See Also==
-*[[Cathepsin|Cathepsin]]
+*[[Cathepsin 3D structures|Cathepsin 3D structures]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:019515558</ref><references group="xtra"/>
+__TOC__
-[[Category: Cathepsin L]]
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Asaad, N.]]
+[[Category: Large Structures]]
-[[Category: Augustin, M.]]
+[[Category: Asaad N]]
-[[Category: Bethel, P A.]]
+[[Category: Augustin M]]
-[[Category: Coulson, M D.]]
+[[Category: Bethel PA]]
-[[Category: Dawson, J.]]
+[[Category: Coulson MD]]
-[[Category: Ford, S J.]]
+[[Category: Dawson J]]
-[[Category: Gerhardt, S.]]
+[[Category: Ford SJ]]
-[[Category: Grist, M.]]
+[[Category: Gerhardt S]]
-[[Category: Hamlin, G A.]]
+[[Category: Grist M]]
-[[Category: James, M J.]]
+[[Category: Hamlin GA]]
-[[Category: Jones, E V.]]
+[[Category: James MJ]]
-[[Category: Karoutchi, G I.]]
+[[Category: Jones EV]]
-[[Category: Kenny, P W.]]
+[[Category: Karoutchi GI]]
-[[Category: Krapp, S.]]
+[[Category: Kenny PW]]
-[[Category: Morley, A D.]]
+[[Category: Krapp S]]
-[[Category: Oldham, K.]]
+[[Category: Morley AD]]
-[[Category: Rankine, N.]]
+[[Category: Oldham K]]
-[[Category: Ryan, D.]]
+[[Category: Rankine N]]
-[[Category: Simader, H.]]
+[[Category: Ryan D]]
-[[Category: Steinbacher, S.]]
+[[Category: Simader H]]
-[[Category: Wells, S L.]]
+[[Category: Steinbacher S]]
-[[Category: Wood, L.]]
+[[Category: Wells SL]]
-[[Category: Cathepsin l]]
+[[Category: Wood L]]
-[[Category: Disulfide bond]]
-[[Category: Glycoprotein]]
-[[Category: Hydrolase]]
-[[Category: Inhibitor]]
-[[Category: Lysosome]]
-[[Category: Protease]]
-[[Category: Proteros biostructures gmbh]]
-[[Category: Thiol protease]]
-[[Category: Zymogen]]