3hha: Difference between revisions

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-[[Image:3hha.png|left|200px]]
-<!--
+==Crystal structure of cathepsin L in complex with AZ12878478==
-The line below this paragraph, containing "STRUCTURE_3hha", creates the "Structure Box" on the page.
+<StructureSection load='3hha' size='340' side='right'caption='[[3hha]], [[Resolution|resolution]] 1.27&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3hha]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HHA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HHA FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.27&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NOW:NALPHA-[(3-TERT-BUTYL-1-METHYL-1H-PYRAZOL-5-YL)CARBONYL]-N-[(2Z)-2-IMINOETHYL]-3-METHYL-L-PHENYLALANINAMIDE'>NOW</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
-{{STRUCTURE_3hha|  PDB=3hha  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hha FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hha OCA], [https://pdbe.org/3hha PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hha RCSB], [https://www.ebi.ac.uk/pdbsum/3hha PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hha ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CATL1_HUMAN CATL1_HUMAN] Important for the overall degradation of proteins in lysosomes.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hh/3hha_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hha ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+A series of potent Cathepsin L inhibitors with good selectivity with respect to other cysteine Cathepsins is described and SAR is discussed with reference to the crystal structure of a protein-ligand complex.
-===Crystal structure of cathepsin L in complex with AZ12878478===
+Dipeptidyl nitrile inhibitors of Cathepsin L.,Asaad N, Bethel PA, Coulson MD, Dawson JE, Ford SJ, Gerhardt S, Grist M, Hamlin GA, James MJ, Jones EV, Karoutchi GI, Kenny PW, Morley AD, Oldham K, Rankine N, Ryan D, Wells SL, Wood L, Augustin M, Krapp S, Simader H, Steinbacher S Bioorg Med Chem Lett. 2009 Aug 1;19(15):4280-3. Epub 2009 May 27. PMID:19515558<ref>PMID:19515558</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-<!--
+</div>
-The line below this paragraph, {{ABSTRACT_PUBMED_19515558}}, adds the Publication Abstract to the page
+<div class="pdbe-citations 3hha" style="background-color:#fffaf0;"></div>
-(as it appears on PubMed at http://www.pubmed.gov), where 19515558 is the PubMed ID number.
--->
-{{ABSTRACT_PUBMED_19515558}}
-==About this Structure==
-[[3hha]] is a 4 chain structure of [[Cathepsin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HHA OCA].
 ==See Also==
-*[[Cathepsin]]
+*[[Cathepsin 3D structures|Cathepsin 3D structures]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:19515558</ref><references group="xtra"/>
+__TOC__
-[[Category: Cathepsin L]]
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Asaad, N.]]
+[[Category: Large Structures]]
-[[Category: Augustin, M.]]
+[[Category: Asaad N]]
-[[Category: Bethel, P A.]]
+[[Category: Augustin M]]
-[[Category: Coulson, M D.]]
+[[Category: Bethel PA]]
-[[Category: Dawson, J.]]
+[[Category: Coulson MD]]
-[[Category: Ford, S J.]]
+[[Category: Dawson J]]
-[[Category: Gerhardt, S.]]
+[[Category: Ford SJ]]
-[[Category: Grist, M.]]
+[[Category: Gerhardt S]]
-[[Category: Hamlin, G A.]]
+[[Category: Grist M]]
-[[Category: James, M J.]]
+[[Category: Hamlin GA]]
-[[Category: Jones, E V.]]
+[[Category: James MJ]]
-[[Category: Karoutchi, G I.]]
+[[Category: Jones EV]]
-[[Category: Kenny, P W.]]
+[[Category: Karoutchi GI]]
-[[Category: Krapp, S.]]
+[[Category: Kenny PW]]
-[[Category: Morley, A D.]]
+[[Category: Krapp S]]
-[[Category: Oldham, K.]]
+[[Category: Morley AD]]
-[[Category: Rankine, N.]]
+[[Category: Oldham K]]
-[[Category: Ryan, D.]]
+[[Category: Rankine N]]
-[[Category: Simader, H.]]
+[[Category: Ryan D]]
-[[Category: Steinbacher, S.]]
+[[Category: Simader H]]
-[[Category: Wells, S L.]]
+[[Category: Steinbacher S]]
-[[Category: Wood, L.]]
+[[Category: Wells SL]]
-[[Category: Cathepsin l]]
+[[Category: Wood L]]
-[[Category: Disulfide bond]]
-[[Category: Glycoprotein]]
-[[Category: Hydrolase]]
-[[Category: Inhibitor]]
-[[Category: Lysosome]]
-[[Category: Protease]]
-[[Category: Proteros biostructures gmbh]]
-[[Category: Thiol protease]]
-[[Category: Zymogen]]