3hao: Difference between revisions

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-{{Seed}}
-[[Image:3hao.jpg|left|200px]]
-<!--
+==Crystal structure of bacteriorhodopsin mutant L94A crystallized from bicelles==
-The line below this paragraph, containing "STRUCTURE_3hao", creates the "Structure Box" on the page.
+<StructureSection load='3hao' size='340' side='right'caption='[[3hao]], [[Resolution|resolution]] 2.49&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3hao]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Halobacterium_salinarum Halobacterium salinarum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HAO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HAO FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.49&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RET:RETINAL'>RET</scene></td></tr>
-{{STRUCTURE_3hao|  PDB=3hao  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hao FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hao OCA], [https://pdbe.org/3hao PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hao RCSB], [https://www.ebi.ac.uk/pdbsum/3hao PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hao ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/BACR_HALSA BACR_HALSA] Light-driven proton pump.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ha/3hao_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hao ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+A major driving force for water-soluble protein folding is the hydrophobic effect, but membrane proteins cannot make use of this stabilizing contribution in the apolar core of the bilayer. It has been proposed that membrane proteins compensate by packing more efficiently. We therefore investigated packing contributions experimentally by observing the energetic and structural consequences of cavity creating mutations in the core of a membrane protein. We observed little difference in the packing energetics of water and membrane soluble proteins. Our results imply that other mechanisms are employed to stabilize the structure of membrane proteins.
-===Crystal structure of bacteriorhodopsin mutant L94A crystallized from bicelles===
+Similar energetic contributions of packing in the core of membrane and water-soluble proteins.,Joh NH, Oberai A, Yang D, Whitelegge JP, Bowie JU J Am Chem Soc. 2009 Aug 12;131(31):10846-7. PMID:19603754<ref>PMID:19603754</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 3hao" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_19603754}}, adds the Publication Abstract to the page
+*[[Bacteriorhodopsin 3D structures|Bacteriorhodopsin 3D structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 19603754 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_19603754}}
+__TOC__
+</StructureSection>
-==About this Structure==
-HAO is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Halobacterium_salinarum Halobacterium salinarum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HAO OCA].
-==Reference==
-<ref group="xtra">PMID:19603754</ref><references group="xtra"/>
 [[Category: Halobacterium salinarum]]
-[[Category: Bowie, J U.]]
+[[Category: Large Structures]]
-[[Category: Joh, N H.]]
+[[Category: Bowie JU]]
-[[Category: Yang, D.]]
+[[Category: Joh NH]]
-[[Category: Bacteriorhodopsin]]
+[[Category: Yang D]]
-[[Category: Cell membrane]]
-[[Category: Chromophore]]
-[[Category: Evolutionary constraint]]
-[[Category: Helical membrane protein]]
-[[Category: Hydrogen ion transport]]
-[[Category: Integral membrane protein]]
-[[Category: Ion transport]]
-[[Category: Membrane]]
-[[Category: Membrane protein]]
-[[Category: Packing force]]
-[[Category: Photoreceptor protein]]
-[[Category: Proton transport]]
-[[Category: Pyrrolidone carboxylic acid]]
-[[Category: Receptor]]
-[[Category: Retinal protein]]
-[[Category: Sensory transduction]]
-[[Category: Transmembrane]]
-[[Category: Transport]]
-[[Category: Transport protein]]
-[[Category: Van der waal]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 23 08:49:19 2009''