3gzd: Difference between revisions
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==Human selenocysteine lyase, P1 crystal form== | ==Human selenocysteine lyase, P1 crystal form== | ||
<StructureSection load='3gzd' size='340' side='right' caption='[[3gzd]], [[Resolution|resolution]] 1.80Å' scene=''> | <StructureSection load='3gzd' size='340' side='right'caption='[[3gzd]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3gzd]] is a 4 chain structure with sequence from [ | <table><tr><td colspan='2'>[[3gzd]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GZD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GZD FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | ||
<tr><td class="sblockLbl"><b>[[ | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSS:S-MERCAPTOCYSTEINE'>CSS</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=PLR:(5-HYDROXY-4,6-DIMETHYLPYRIDIN-3-YL)METHYL+DIHYDROGEN+PHOSPHATE'>PLR</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gzd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gzd OCA], [https://pdbe.org/3gzd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gzd RCSB], [https://www.ebi.ac.uk/pdbsum/3gzd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gzd ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | [https://www.uniprot.org/uniprot/SCLY_HUMAN SCLY_HUMAN] Catalyzes the decomposition of L-selenocysteine to L-alanine and elemental selenium (By similarity). | ||
<table> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gz/3gzd_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gz/3gzd_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/ | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gzd ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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Biochemical discrimination between selenium and sulfur 1: a single residue provides selenium specificity to human selenocysteine lyase.,Collins R, Johansson AL, Karlberg T, Markova N, van den Berg S, Olesen K, Hammarstrom M, Flores A, Schuler H, Schiavone LH, Brzezinski P, Arner ES, Hogbom M PLoS One. 2012;7(1):e30581. Epub 2012 Jan 25. PMID:22295093<ref>PMID:22295093</ref> | Biochemical discrimination between selenium and sulfur 1: a single residue provides selenium specificity to human selenocysteine lyase.,Collins R, Johansson AL, Karlberg T, Markova N, van den Berg S, Olesen K, Hammarstrom M, Flores A, Schuler H, Schiavone LH, Brzezinski P, Arner ES, Hogbom M PLoS One. 2012;7(1):e30581. Epub 2012 Jan 25. PMID:22295093<ref>PMID:22295093</ref> | ||
From | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 3gzd" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Selenocysteine lyase|Selenocysteine lyase]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
| Line 33: | Line 37: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Arrowsmith | [[Category: Arrowsmith CH]] | ||
[[Category: Berglund H]] | |||
[[Category: Berglund | [[Category: Bountra C]] | ||
[[Category: Bountra | [[Category: Collins R]] | ||
[[Category: Collins | [[Category: Edwards AM]] | ||
[[Category: Edwards | [[Category: Flodin S]] | ||
[[Category: Flodin | [[Category: Flores A]] | ||
[[Category: Flores | [[Category: Graslund S]] | ||
[[Category: Graslund | [[Category: Hammarstrom M]] | ||
[[Category: Hammarstrom | [[Category: Hogbom M]] | ||
[[Category: Hogbom | [[Category: Johansson A]] | ||
[[Category: Johansson | [[Category: Johansson I]] | ||
[[Category: Johansson | [[Category: Karlberg T]] | ||
[[Category: Karlberg | [[Category: Kotenyova T]] | ||
[[Category: Kotenyova | [[Category: Moche M]] | ||
[[Category: Moche | [[Category: Nordlund P]] | ||
[[Category: Nordlund | [[Category: Nyman T]] | ||
[[Category: Nyman | [[Category: Persson C]] | ||
[[Category: Persson | [[Category: Sagemark J]] | ||
[[Category: Schuler H]] | |||
[[Category: Sagemark | [[Category: Schutz P]] | ||
[[Category: Schuler | [[Category: Siponen MI]] | ||
[[Category: Schutz | [[Category: Thorsell AG]] | ||
[[Category: Siponen | [[Category: Tresaugues L]] | ||
[[Category: Thorsell | [[Category: Van Den Berg S]] | ||
[[Category: Tresaugues | [[Category: Weigelt J]] | ||
[[Category: | [[Category: Welin M]] | ||
[[Category: | [[Category: Wisniewska M]] | ||
[[Category: | |||
[[Category: | |||