3gio: Difference between revisions

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-[[Image:3gio.png|left|200px]]
-{{STRUCTURE_3gio|  PDB=3gio  |  SCENE=  }}
+==Crystal structure of the TNF-alpha inducing protein (Tip alpha) from Helicobacter pylori==
+<StructureSection load='3gio' size='340' side='right'caption='[[3gio]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3gio]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GIO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GIO FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gio FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gio OCA], [https://pdbe.org/3gio PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gio RCSB], [https://www.ebi.ac.uk/pdbsum/3gio PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gio ProSAT]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Helicobacter pylori infection is one of the highest risk factors for gastroduodenal diseases including gastric cancer. Tumor necrosis factor-alpha (TNF-alpha) is one of the essential cytokines for tumor promotion, and thus, an H. pylori protein that induces TNF-alpha is believed to play a significant role in gastric cancer development in humans. The HP0596 gene product of H. pylori strain 26695 was identified as the TNF-alpha-inducing protein (Tipalpha). Tipalpha is secreted from H. pylori as dimers and enters the gastric cells. It was shown to have a DNA-binding activity. Here, we have determined the crystal structure of Tipalpha from H. pylori. Its monomer consists of two structural domains ("mixed domain" and "helical domain"). Tipalpha exists as a dimer in the crystal, and the dimeric structure represents a novel scaffold for DNA binding. A positively charged surface patch formed across the two monomers of the Tipalpha dimer by the loop between helices alpha1 and alpha2 may be important in DNA binding.
-===Crystal structure of the TNF-alpha inducing protein (Tip alpha) from Helicobacter pylori===
+Crystal structure of the TNF-alpha-Inducing protein (Tipalpha) from Helicobacter pylori: Insights into Its DNA-binding activity.,Jang JY, Yoon HJ, Yoon JY, Kim HS, Lee SJ, Kim KH, Kim do J, Jang S, Han BG, Lee BI, Suh SW J Mol Biol. 2009 Sep 11;392(1):191-7. Epub 2009 Jul 10. PMID:19596016<ref>PMID:19596016</ref>
-{{ABSTRACT_PUBMED_19596016}}
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-==About this Structure==
+<div class="pdbe-citations 3gio" style="background-color:#fffaf0;"></div>
-[[3gio]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GIO OCA].
+== References ==
+<references/>
-==Reference==
+__TOC__
-<ref group="xtra">PMID:019596016</ref><references group="xtra"/>
+</StructureSection>
 [[Category: Helicobacter pylori]]
-[[Category: Han, B G.]]
+[[Category: Large Structures]]
-[[Category: Jang, J Y.]]
+[[Category: Han BG]]
-[[Category: Jang, S.]]
+[[Category: Jang JY]]
-[[Category: Kim, D J.]]
+[[Category: Jang S]]
-[[Category: Kim, H S.]]
+[[Category: Kim DJ]]
-[[Category: Kim, K H.]]
+[[Category: Kim HS]]
-[[Category: Lee, B I.]]
+[[Category: Kim KH]]
-[[Category: Lee, S J.]]
+[[Category: Lee BI]]
-[[Category: Suh, S W.]]
+[[Category: Lee SJ]]
-[[Category: Yoon, H J.]]
+[[Category: Suh SW]]
-[[Category: Yoon, J Y.]]
+[[Category: Yoon HJ]]
-[[Category: Antiparallel beta sheet]]
+[[Category: Yoon JY]]
-[[Category: Dna binding protein]]
-[[Category: Four-helix bundle]]
-[[Category: Loop]]