Antibody: Difference between revisions
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'''Antibodies''', also known as '''Immunoglobulins''' (Ig) are gamma globulin proteins, primarily found in the blood of vertebrates. These [[glycoproteins]] serve as a critical component of the immune system when the host fails to activate alternative compliment pathways or phagocytic cells in response to invading microorganisms or other [http://en.wikipedia.org/wiki/Antigen antigens]. The incredible specificity with which immunoglobulins bind to an antigen is based upon structural complementarity between the antigen and antibody <scene name='Antibody/1hzh_heavy_chains/1'>heavy </scene>and <scene name='Antibody/1hzh_light_chains/1'>light chains </scene>. It is this specificity that has made <scene name='Antibody/1hzh_starting_scene/3'>antibodies</scene> a critical component in laboratory and medical research. <br /> | '''Antibodies''', also known as '''Immunoglobulins''' (Ig) are gamma globulin proteins, primarily found in the blood of vertebrates. These [[glycoproteins]] serve as a critical component of the immune system when the host fails to activate alternative compliment pathways or phagocytic cells in response to invading microorganisms or other [http://en.wikipedia.org/wiki/Antigen antigens]. The incredible specificity with which immunoglobulins bind to an antigen is based upon structural complementarity between the antigen and antibody <scene name='Antibody/1hzh_heavy_chains/1'>heavy </scene>and <scene name='Antibody/1hzh_light_chains/1'>light chains </scene>. It is this specificity that has made <scene name='Antibody/1hzh_starting_scene/3'>antibodies</scene> a critical component in laboratory and medical research. <br /> | ||
'''Humanized mouse antibody (hmFab)''' is a modified mFab which resembles more hFab.<br /> | *'''Humanized mouse antibody (hmFab)''' is a modified mFab which resembles more hFab.<br /> | ||
'''Broadly neutralizing Fab''' and '''Neutralizing Fab''' are anti- | *'''Broadly neutralizing Fab''' and '''Neutralizing Fab''' are anti-virus Fab. <br /> | ||
'''Lama antibodies''' or '''nanobodies''' or '''camelid''' or '''VHH''' are natural single-domain antibodies containing just the heavy chain.<br /> | *'''Intrabody''' is intracellular antibody. <br /> | ||
'''scFv''' is a single chain variable fragment in a fusion protein of the variable regions of the heavy and light chains of immunoglobulin. | *'''Sybody''' is synthetic nanobody (syVHH).<br /> | ||
*'''Diabody''' is a recombinant bispecific antibody constructed from heterogenous single chain antibody. <br /> | |||
*'''Lama antibodies''' or '''nanobodies''' or '''camelid''' or '''VHH''' are natural single-domain antibodies containing just the heavy chain.<br /> | |||
*'''scFv''' is a '''single chain variable fragment''' in a fusion protein of the variable regions of the heavy and light chains of immunoglobulin. <br /> | |||
*'''VH domain''' is the variable domain of the antibody heavy chain.<br /> | |||
*'''Bispecific antibody''' or '''biparatopic antibody''' can bind to two epitopes of an antigen simultaneously.<br /> | |||
*'''Polyclonal antibodies''' are a mixture of antibodies that bind to several epitopes of an antigen simultaneously.<br /> | |||
*'''Ultralong antibody''' is found in bovine. It has unusually long CDR H3 regions and has more effective defence against disease than typical antibodis <br /> | |||
See more in<br /> | See more in<br /> | ||