Antibody: Difference between revisions

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Eric Martz, David Canner, Wayne Decatur, Alexander Berchansky, Michal Harel, Mark Hoelzer

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 <StructureSection load='1hzh' size='350' side='right' scene='' caption='Glycosylated human Igg with heavy chains (red and light red), light chains (aqua and green) (PDB code [[1hzh]])'>
-'''Antibodies''', also known as '''Immunoglobulins''' (Ig) are gamma globulin proteins, primarily found in the blood of vertebrates.  These [[glycoproteins]] serve as a critical component of the immune system when the host fails to activate alternative compliment pathways or phagocytic cells in response to invading microorganisms or other [http://en.wikipedia.org/wiki/Antigen antigens]. The incredible specificity with which immunoglobulins bind to an antigen is based upon structural complementarity between the antigen and antibody <scene name='Antibody/1hzh_heavy_chains/1'>heavy </scene>and <scene name='Antibody/1hzh_light_chains/1'>light chains </scene>. It is this specificity that has made <scene name='Antibody/1hzh_starting_scene/3'>antibodies</scene> a critical component in laboratory and medical research.  See more in<br />
+'''Antibodies''', also known as '''Immunoglobulins''' (Ig) are gamma globulin proteins, primarily found in the blood of vertebrates.  These [[glycoproteins]] serve as a critical component of the immune system when the host fails to activate alternative compliment pathways or phagocytic cells in response to invading microorganisms or other [http://en.wikipedia.org/wiki/Antigen antigens]. The incredible specificity with which immunoglobulins bind to an antigen is based upon structural complementarity between the antigen and antibody <scene name='Antibody/1hzh_heavy_chains/1'>heavy </scene>and <scene name='Antibody/1hzh_light_chains/1'>light chains </scene>. It is this specificity that has made <scene name='Antibody/1hzh_starting_scene/3'>antibodies</scene> a critical component in laboratory and medical research. <br />
+*'''Humanized mouse antibody (hmFab)''' is a modified mFab which resembles more hFab.<br />
+*'''Broadly neutralizing Fab''' and '''Neutralizing Fab''' are anti-virus Fab. <br />
+*'''Intrabody''' is intracellular antibody. <br />
+*'''Sybody''' is synthetic nanobody (syVHH).<br />
+*'''Diabody''' is a recombinant bispecific antibody constructed from heterogenous single chain antibody. <br />
+*'''Lama antibodies''' or '''nanobodies''' or '''camelid''' or '''VHH''' are natural single-domain antibodies containing just the heavy chain.<br />
+*'''scFv''' is a '''single chain variable fragment''' in a fusion protein of the variable regions of the heavy and light chains of immunoglobulin. <br />
+*'''VH domain''' is the variable domain of the antibody heavy chain.<br />
+*'''Bispecific antibody''' or '''biparatopic antibody''' can bind to two epitopes of an antigen simultaneously.<br />
+*'''Polyclonal antibodies''' are a mixture of antibodies that bind to several epitopes of an antigen simultaneously.<br />
+*'''Ultralong antibody''' is found in bovine.  It has unusually long CDR H3 regions and has more effective defence against disease than typical antibodis <br />
+See more in<br />
 [[IgA]]<br />
 [[IgG Branco]]<br />
 [[Monoclonal Antibody]].<br />
-For Anti-HIV Fab see [[Human Fab PG16]]<br />
+For Anti-HIV-1 antibodies see [[Human Fab PG16]] and [[VRC01 gp120 complex|VRC01 and VRC01-like antibodies are important in neutralizing HIV-1]]<br />
 For Anti-VEGF Fab see [[Bevacizumab]] (Avastin)<br />
 For Anti-factor IX Fab see [[Conformation-specific anti-Factor IX antibodies]]<br />
+For blue luminescent Fab see [[Blue Luminescent Antibody Derived from House Mouse]]<br />
 For Anti-vitamin Fab see [[MR1 Binds Vitamin Metabolites]]<br />.
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 The last two decades have seen a dramatic increase in antibody based technologies both for the lab and medicine thanks to the invention of the monoclonal antiboy, a discovery that won Niels K. Jerne, Georges J.F. Köhler, César Milstein the [http://nobelprize.org/nobel_prizes/medicine/laureates/1984/press.html Nobel Prize in Medicine in 1984]. See: [[Monoclonal Antibody]] for additional information.
+==3D structures of antibody==
+[[3D structures of antibody]]
 </StructureSection>
 __NOTOC__