3gci: Difference between revisions

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[[Image:3gci.png|left|200px]]


{{STRUCTURE_3gci|  PDB=3gci  |  SCENE=  }}
==Crystal Structure of the Complex Formed Between a New Isoform of Phospholipase A2 with C-terminal Amyloid Beta Heptapeptide at 2 A Resolution==
 
<StructureSection load='3gci' size='340' side='right'caption='[[3gci]], [[Resolution|resolution]] 2.04&Aring;' scene=''>
===Crystal Structure of the Complex Formed Between a New Isoform of Phospholipase A2 with C-terminal Amyloid Beta Heptapeptide at 2 A Resolution===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3gci]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Naja_sagittifera Naja sagittifera]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GCI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GCI FirstGlance]. <br>
 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.04&#8491;</td></tr>
==About this Structure==
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
[[3gci]] is a 2 chain structure of [[Amyloid precursor protein]] and [[Phospholipase A2]] with sequence from [http://en.wikipedia.org/wiki/Naja_sagittifera Naja sagittifera]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GCI OCA].  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gci FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gci OCA], [https://pdbe.org/3gci PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gci RCSB], [https://www.ebi.ac.uk/pdbsum/3gci PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gci ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PA2A3_NAJSG PA2A3_NAJSG] PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gc/3gci_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gci ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Amyloid precursor protein|Amyloid precursor protein]]
*[[Amyloid precursor protein 3D structures|Amyloid precursor protein 3D structures]]
*[[Phospholipase A2|Phospholipase A2]]
*[[Phospholipase A2 3D structures|Phospholipase A2 3D structures]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Naja sagittifera]]
[[Category: Naja sagittifera]]
[[Category: Bhushan, A.]]
[[Category: Bhushan A]]
[[Category: Kaur, P.]]
[[Category: Kaur P]]
[[Category: Mirza, Z.]]
[[Category: Mirza Z]]
[[Category: Sharma, S.]]
[[Category: Sharma S]]
[[Category: Singh, N.]]
[[Category: Singh N]]
[[Category: Singh, T P.]]
[[Category: Singh TP]]
[[Category: Sinha, M.]]
[[Category: Sinha M]]
[[Category: Srinivasan, A.]]
[[Category: Srinivasan A]]
[[Category: Vikram, G.]]
[[Category: Vikram G]]
[[Category: Amyloid beta]]
[[Category: Heptapeptide]]
[[Category: Hydrolase]]
[[Category: Lipid degradation]]
[[Category: Metal-binding]]
[[Category: Phospholipase a2]]
[[Category: Secreted]]

Latest revision as of 12:54, 6 November 2024

Crystal Structure of the Complex Formed Between a New Isoform of Phospholipase A2 with C-terminal Amyloid Beta Heptapeptide at 2 A ResolutionCrystal Structure of the Complex Formed Between a New Isoform of Phospholipase A2 with C-terminal Amyloid Beta Heptapeptide at 2 A Resolution

Structural highlights

3gci is a 2 chain structure with sequence from Homo sapiens and Naja sagittifera. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.04Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PA2A3_NAJSG PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

3gci, resolution 2.04Å

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