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==Crystal structure of the Endonuclease_V (BSU36170) from Bacillus subtilis, Northeast Structural Genomics Consortium Target SR624== | ==Crystal structure of the Endonuclease_V (BSU36170) from Bacillus subtilis, Northeast Structural Genomics Consortium Target SR624== | ||
<StructureSection load='3ga2' size='340' side='right' caption='[[3ga2]], [[Resolution|resolution]] 2.10Å' scene=''> | <StructureSection load='3ga2' size='340' side='right'caption='[[3ga2]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3ga2]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[3ga2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GA2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GA2 FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | ||
<tr><td class="sblockLbl"><b> | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ga2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ga2 OCA], [https://pdbe.org/3ga2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ga2 RCSB], [https://www.ebi.ac.uk/pdbsum/3ga2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ga2 ProSAT], [https://www.topsan.org/Proteins/NESGC/3ga2 TOPSAN]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/NFI_BACSU NFI_BACSU] Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity). | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ga/3ga2_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ga/3ga2_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/ | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ga2 ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
*[[Endonuclease|Endonuclease]] | *[[Endonuclease 3D structures|Endonuclease 3D structures]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Bacillus subtilis]] | [[Category: Bacillus subtilis]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Abashidze | [[Category: Abashidze M]] | ||
[[Category: Acton | [[Category: Acton TB]] | ||
[[Category: Cunningham | [[Category: Cunningham K]] | ||
[[Category: Everett | [[Category: Everett JK]] | ||
[[Category: Fang | [[Category: Fang Y]] | ||
[[Category: Forouhar | [[Category: Forouhar F]] | ||
[[Category: Hunt | [[Category: Hunt JF]] | ||
[[Category: Hussain | [[Category: Hussain M]] | ||
[[Category: Janjua | [[Category: Janjua H]] | ||
[[Category: Ma | [[Category: Ma L-C]] | ||
[[Category: Montelione | [[Category: Montelione GT]] | ||
[[Category: Nair R]] | |||
[[Category: Nair | [[Category: Owens L]] | ||
[[Category: Owens | [[Category: Rost B]] | ||
[[Category: Rost | [[Category: Seetharaman J]] | ||
[[Category: Seetharaman | [[Category: Tong L]] | ||
[[Category: Tong | [[Category: Wang D]] | ||
[[Category: Wang | [[Category: Xiao R]] | ||
[[Category: Xiao | |||
Latest revision as of 08:50, 17 October 2024
Crystal structure of the Endonuclease_V (BSU36170) from Bacillus subtilis, Northeast Structural Genomics Consortium Target SR624Crystal structure of the Endonuclease_V (BSU36170) from Bacillus subtilis, Northeast Structural Genomics Consortium Target SR624
Structural highlights
FunctionNFI_BACSU Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity). Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also |
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