3g5c: Difference between revisions

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-[[Image:3g5c.png|left|200px]]
-<!--
+==Structural and biochemical studies on the ectodomain of human ADAM22==
-The line below this paragraph, containing "STRUCTURE_3g5c", creates the "Structure Box" on the page.
+<StructureSection load='3g5c' size='340' side='right'caption='[[3g5c]], [[Resolution|resolution]] 2.36&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3g5c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G5C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3G5C FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.36&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-{{STRUCTURE_3g5c|  PDB=3g5c  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3g5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g5c OCA], [https://pdbe.org/3g5c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3g5c RCSB], [https://www.ebi.ac.uk/pdbsum/3g5c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3g5c ProSAT]</span></td></tr>
+</table>
-===Structural and biochemical studies on the ectodomain of human ADAM22===
+== Function ==
+[https://www.uniprot.org/uniprot/ADA22_HUMAN ADA22_HUMAN] Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1.<ref>PMID:12589811</ref> <ref>PMID:15882968</ref> <ref>PMID:16385342</ref>
+== Evolutionary Conservation ==
-==About this Structure==
+[[Image:Consurf_key_small.gif|200px|right]]
-[[3g5c]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G5C OCA].
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g5/3g5c_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3g5c ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Molecular Playground/ADAM13]]
+*[[A Disintegrin And Metalloproteinase 3D structures|A Disintegrin And Metalloproteinase 3D structures]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Chen, X.]]
+[[Category: Large Structures]]
-[[Category: He, X.]]
+[[Category: Chen X]]
-[[Category: Liu, H.]]
+[[Category: He X]]
-[[Category: Shim, A.]]
+[[Category: Liu H]]
-[[Category: Alpha/beta fold]]
+[[Category: Shim A]]
-[[Category: Alternative splicing]]
-[[Category: Cell adhesion]]
-[[Category: Cleavage on pair of basic residue]]
-[[Category: Cross-linked domain]]
-[[Category: Egf-like domain]]
-[[Category: Glycoprotein]]
-[[Category: Membrane]]
-[[Category: Membrane protein]]
-[[Category: Phosphoprotein]]
-[[Category: Polymorphism]]
-[[Category: Transmembrane]]