Sodium-hydrogen exchange regulatory factor: Difference between revisions
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== Function == | == Function == | ||
'''Sodium-hydrogen exchange regulatory factors''' (NHERF) or '''ezrin-radixin-moesin binding phosphoprotein-50''' or '''PDZ domain-containing protein''' or '''Na+/H+ exchange regulatory cofactor NHE-RF1''' or '''NHERF''' are multifunctional adaptor protein which plays a role in the assembly of signal transduction complexes, linking ion channels and receptors to the actin skeleton<ref>PMID:11141479</ref>. | '''Sodium-hydrogen exchange regulatory factors''' (NHERF) or '''ezrin-radixin-moesin binding phosphoprotein-50''' or '''PDZ domain-containing protein''' or '''Na+/H+ exchange regulatory cofactor NHE-RF1''' or '''NHERF''' are multifunctional adaptor protein which plays a role in the assembly of signal transduction complexes, linking ion channels and receptors to the actin skeleton<ref>PMID:11141479</ref>. | ||
* '''NHERF-1''' is the major isoform present in the brain and it regulates the trans-cellular ion transport through the blood-brain barrier membrane<ref>PMID:26010555</ref>. It transduces cyclic AMP signals that inhibit the sodium-hydrogen exchanger present at the surface of kidney and gut<ref>PMID:12586353</ref>. NHERF-1 contains 2 PDZ domains and one erm domain. | |||
* '''NHERF-2''' is a negative regulator of endothelial proliferation and may have important roles in endothelial homeostasis and vascular modeling<ref>PMID:22343917</ref>. NHERF-2 contains 2 PDZ domains and one erm domain. | |||
*'''NHERF-3''' contains 4 PDZ domains no erm domain<ref>PMID:15905209</ref>. | |||
== Relevance == | == Relevance == | ||