5ueh: Difference between revisions

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==Structure of GSTO1 covalently conjugated to quinolinic acid fluorosulfate==
==Structure of GSTO1 covalently conjugated to quinolinic acid fluorosulfate==
<StructureSection load='5ueh' size='340' side='right' caption='[[5ueh]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='5ueh' size='340' side='right'caption='[[5ueh]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5ueh]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UEH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UEH FirstGlance]. <br>
<table><tr><td colspan='2'>[[5ueh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UEH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UEH FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=85P:2-(4-chlorophenyl)-6-[(fluorosulfonyl)oxy]quinoline-4-carboxylic+acid'>85P</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ueh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ueh OCA], [http://pdbe.org/5ueh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ueh RCSB], [http://www.ebi.ac.uk/pdbsum/5ueh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ueh ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=85P:2-(4-chlorophenyl)-6-fluorosulfonyloxy-quinoline-4-carboxylic+acid'>85P</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ueh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ueh OCA], [https://pdbe.org/5ueh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ueh RCSB], [https://www.ebi.ac.uk/pdbsum/5ueh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ueh ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/GSTO1_HUMAN GSTO1_HUMAN]] Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid.<ref>PMID:10783391</ref> <ref>PMID:11511179</ref> <ref>PMID:17226937</ref> <ref>PMID:18028863</ref> <ref>PMID:21106529</ref>
[https://www.uniprot.org/uniprot/GSTO1_HUMAN GSTO1_HUMAN] Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid.<ref>PMID:10783391</ref> <ref>PMID:11511179</ref> <ref>PMID:17226937</ref> <ref>PMID:18028863</ref> <ref>PMID:21106529</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5ueh" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5ueh" style="background-color:#fffaf0;"></div>
==See Also==
*[[Glutathione S-transferase 3D structures|Glutathione S-transferase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Kelly, J W]]
[[Category: Homo sapiens]]
[[Category: Mortenson, D E]]
[[Category: Large Structures]]
[[Category: Wilson, I A]]
[[Category: Kelly JW]]
[[Category: Arylfluorosulfate]]
[[Category: Mortenson DE]]
[[Category: Covalent inhibitor]]
[[Category: Wilson IA]]
[[Category: Gst]]
[[Category: Transferase-oxidoreductase complex]]

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