Contactin: Difference between revisions
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== Function == | == Function == | ||
'''Contactin''' (CNTN) is a neuronal cell surface glycoprotein which associates with sodium channel and enhances the density of these channels on the plasma membrane in mammalian expression systems<ref>PMID:16029194</ref>. | '''Contactin''' (CNTN) is a neuronal cell surface glycoprotein which associates with sodium channel and enhances the density of these channels on the plasma membrane in mammalian expression systems<ref>PMID:16029194</ref>. | ||
*'''Contactin-2''' is a synaptic membrane protein involved in pathology of Alzheimer Disease<ref>PMID:29859129</ref>. | |||
*'''Contactin-4''' ,''' contactin-5''' and '''contactin-6''' are involved in brain developmen<ref>PMID:23519440</ref>. | |||
== Disease == | == Disease == | ||
contactin-4 | Mutations in contactin-4, contactin-5 and contactin-6 confer risk of autism <ref>PMID:21308999</ref>. | ||
</StructureSection> | </StructureSection> | ||
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* Contactin-1 | * Contactin-1 | ||
**[[3s97]] – hCNTN Ig2-Ig3 domains + receptor-type tyrosine-protein phosphatase ζ - human <br /> | |||
**[[3s97]] – hCNTN Ig2-Ig3 domains + receptor-type tyrosine-protein phosphatase | **[[2ee2]] – hCNTN FN3 domains 798-903 - NMR <br /> | ||
**[[2ee2]] – hCNTN FN3 domains - NMR <br /> | **[[7ol2]] – mCNTN Ig1-Ig6 domains 28-608 - mouse <br /> | ||
**[[5e53]] – cCNTN FN1-FN3 domains 601-893 – chicken <br /> | |||
* Contactin-2 | * Contactin-2 | ||
**[[5e7l]] – mCNTN FN1-FN3 domains – | **[[8k53]], [[9ba4]] – hCNTN – Cryo EM <br /> | ||
**[[ | **[[2om5]] – hCNTN Ig1-Ig4 domains 34-414 <br /> | ||
**[[8k3j]] – hCNTN Ig1-Ig6<br /> | |||
**[[9ba5]] – hCNTN Ig1-Ig6 – Cryo EM<br /> | |||
**[[5e7l]] – mCNTN FN1-FN3 domains 609-911 <br/ > | |||
**[[8a0y]] – mCNTN Ig1-Ig6 domains 28-608 <br /> | |||
**[[7ol4]] – mCNTN Ig1-Ig6 domains + neurofascin<br /> | |||
* Contactin-3 | * Contactin-3 | ||
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**[[5e4q]] – mCNTN FN1-FN3 domains <br /> | **[[5e4q]] – mCNTN FN1-FN3 domains <br /> | ||
**[[5i99]] – mCNTN Ig5-FN2 domains <br /> | **[[5i99]] – mCNTN Ig5-FN2 domains <br /> | ||
**[[5e5r]] – mCNTN Ig2-Ig3 domains + receptor-type tyrosine-protein phosphatase | **[[5e5r]] – mCNTN Ig2-Ig3 domains + receptor-type tyrosine-protein phosphatase γ <br /> | ||
**[[7mrm]] – cCNTN FN1-FN2 domains + APPb<br /> | |||
* Contactin-4 | * Contactin-4 | ||
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**[[5e4s]] – mCNTN FN1-FN3 domains <br /> | **[[5e4s]] – mCNTN FN1-FN3 domains <br /> | ||
**[[3jxa]] – mCNTN Ig1-Ig4 domains <br /> | **[[3jxa]] – mCNTN Ig1-Ig4 domains <br /> | ||
**[[3kld]] – mCNTN Ig2-Ig3 domains + receptor-type tyrosine-protein phosphatase | **[[3kld]] – mCNTN Ig2-Ig3 domains + receptor-type tyrosine-protein phosphatase γ <br /> | ||
**[[7mrq]] – cCNTN FN1-FN3 domains <br /> | |||
**[[7mro]] – zCNTN FN1-FN3 domains 600-903 – zebrafish<br /> | |||
**[[7mrk]], [[7mrs]] – zCNTN FN1-FN3 domains + APPb<br /> | |||
**[[7mqy]] – zCNTN FN1-FN3 domains + APLP2<br /> | |||
* Contactin-5 | * Contactin-5 | ||
**[[5e52]] – hCNTN FN1-FN3 domains <br /> | **[[5e52]] – hCNTN FN1-FN3 domains <br /> | ||
**[[4n68]] – hCNTN FN3 domains <br /> | **[[4n68]] – hCNTN FN3 domains <br /> | ||
**[[5e4i]] – mCNTN Ig1-Ig4 domains 96-477 <br /> | |||
**[[7mrn]] – mCNTN FN1-FN3 domains 669-970 + APP<br /> | |||
* Contactin-6 | * Contactin-6 | ||
Latest revision as of 13:45, 6 February 2025
FunctionContactin (CNTN) is a neuronal cell surface glycoprotein which associates with sodium channel and enhances the density of these channels on the plasma membrane in mammalian expression systems[1].
DiseaseMutations in contactin-4, contactin-5 and contactin-6 confer risk of autism [4].
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3D structures of contactin3D structures of contactin
Updated on 06-February-2025
ReferencesReferences
- ↑ Rush AM, Craner MJ, Kageyama T, Dib-Hajj SD, Waxman SG, Ranscht B. Contactin regulates the current density and axonal expression of tetrodotoxin-resistant but not tetrodotoxin-sensitive sodium channels in DRG neurons. Eur J Neurosci. 2005 Jul;22(1):39-49. PMID:16029194 doi:http://dx.doi.org/10.1111/j.1460-9568.2005.04186.x
- ↑ Chatterjee M, Del Campo M, Morrema THJ, de Waal M, van der Flier WM, Hoozemans JJM, Teunissen CE. Contactin-2, a synaptic and axonal protein, is reduced in cerebrospinal fluid and brain tissue in Alzheimer's disease. Alzheimers Res Ther. 2018 Jun 1;10(1):52. PMID:29859129 doi:10.1186/s13195-018-0383-x
- ↑ Mercati O, Danckaert A, André-Leroux G, Bellinzoni M, Gouder L, Watanabe K, Shimoda Y, Grailhe R, De Chaumont F, Bourgeron T, Cloëz-Tayarani I. Contactin 4, -5 and -6 differentially regulate neuritogenesis while they display identical PTPRG binding sites. Biol Open. 2013 Mar 15;2(3):324-34. PMID:23519440 doi:10.1242/bio.20133343
- ↑ Cottrell CE, Bir N, Varga E, Alvarez CE, Bouyain S, Zernzach R, Thrush DL, Evans J, Trimarchi M, Butter EM, Cunningham D, Gastier-Foster JM, McBride KL, Herman GE. Contactin 4 as an autism susceptibility locus. Autism Res. 2011 Jun;4(3):189-99. doi: 10.1002/aur.184. Epub 2011 Feb 9. PMID:21308999 doi:http://dx.doi.org/10.1002/aur.184