3ex3: Difference between revisions

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 ==human orotidyl-5'-monophosphate decarboxylase in complex with 6-azido-UMP, covalent adduct==
-<StructureSection load='3ex3' size='340' side='right' caption='[[3ex3]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
+<StructureSection load='3ex3' size='340' side='right'caption='[[3ex3]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[3ex3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EX3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EX3 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[3ex3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EX3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EX3 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=U5P:URIDINE-5-MONOPHOSPHATE'>U5P</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ewu|3ewu]], [[3eww|3eww]], [[3ewx|3ewx]], [[3ewy|3ewy]], [[3ewz|3ewz]], [[3ex0|3ex0]], [[3ex1|3ex1]], [[3ex2|3ex2]], [[3ex4|3ex4]], [[3ex5|3ex5]], [[3ex6|3ex6]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=U5P:URIDINE-5-MONOPHOSPHATE'>U5P</scene></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">UMPS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ex3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ex3 OCA], [https://pdbe.org/3ex3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ex3 RCSB], [https://www.ebi.ac.uk/pdbsum/3ex3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ex3 ProSAT]</span></td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Orotidine-5'-phosphate_decarboxylase Orotidine-5'-phosphate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.23 4.1.1.23] </span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ex3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ex3 OCA], [http://pdbe.org/3ex3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ex3 RCSB], [http://www.ebi.ac.uk/pdbsum/3ex3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ex3 ProSAT]</span></td></tr>
 </table>
 == Disease ==
-[[http://www.uniprot.org/uniprot/UMPS_HUMAN UMPS_HUMAN]] Defects in UMPS are the cause of orotic aciduria type 1 (ORAC1) [MIM:[http://omim.org/entry/258900 258900]]. A disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and mental retardation. A minority of cases have additional features, particularly congenital malformations and immune deficiencies.<ref>PMID:9042911</ref>
+[https://www.uniprot.org/uniprot/UMPS_HUMAN UMPS_HUMAN] Defects in UMPS are the cause of orotic aciduria type 1 (ORAC1) [MIM:[https://omim.org/entry/258900 258900]. A disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and mental retardation. A minority of cases have additional features, particularly congenital malformations and immune deficiencies.<ref>PMID:9042911</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/UMPS_HUMAN UMPS_HUMAN]
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
 Check<jmol>
    <jmolCheckbox>
-     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ex/3ex3_consurf.spt"</scriptWhenChecked>
+     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ex/3ex3_consurf.spt"</scriptWhenChecked>
-     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
      <text>to colour the structure by Evolutionary Conservation</text>
    </jmolCheckbox>
@@ Line 31: / Line 31: @@
 </div>
 <div class="pdbe-citations 3ex3" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Uridine 5'-monophosphate synthase 3D structures|Uridine 5'-monophosphate synthase 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
-[[Category: Orotidine-5'-phosphate decarboxylase]]
+[[Category: Large Structures]]
-[[Category: Diederichsen, U]]
+[[Category: Diederichsen U]]
-[[Category: Heinrich, D]]
+[[Category: Heinrich D]]
-[[Category: Rudolph, M]]
+[[Category: Rudolph M]]
-[[Category: Decarboxylase]]
-[[Category: Disease mutation]]
-[[Category: Glycosyltransferase]]
-[[Category: Lyase]]
-[[Category: Multifunctional enzyme]]
-[[Category: Pyrimidine biosynthesis]]
-[[Category: Tim barrel]]
-[[Category: Transferase]]
-[[Category: Unusual catalysis]]