Nobel Prizes for 3D Molecular Structure: Difference between revisions
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* 1985: [http://nobelprize.org/nobel_prizes/chemistry/laureates/1985/index.html Herbert A. Hauptman and Jerome Karle] (Chemistry) "for their outstanding achievements in the development of '''direct''' methods for the determination of crystal structures". | * 1985: [http://nobelprize.org/nobel_prizes/chemistry/laureates/1985/index.html Herbert A. Hauptman and Jerome Karle] (Chemistry) "for their outstanding achievements in the development of '''direct''' methods for the determination of crystal structures". | ||
* 2011: [http://nobelprize.org/nobel_prizes/chemistry/laureates/2011/index.html Dan Shechtman] (Chemistry) "for the discovery of quasicrystals". | |||
* 2013: [https://www.nobelprize.org/prizes/chemistry/2013/summary Martin Karplus Michael Levitt & Arieh Warshel] "for the development of multiscale models for complex chemical systems" | |||
==Nobel Prizes for 3D Macromolecular Structure and Structure Determination Methods== | ==Nobel Prizes for 3D Macromolecular Structure and Structure Determination Methods== | ||
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===Twenty-First Century=== | ===Twenty-First Century=== | ||
====2000-2009==== | |||
* 2002: [http://nobelprize.org/nobel_prizes/chemistry/laureates/2002/index.html John B. Fenn, Koichi Tanaka, and Kurt Wüthrich] (Chemistry) "for the development of methods for identification and structure analyses of biological macromolecules". Fenn and Tanaka each were awarded one quarter of the prize "for their development of soft desorption ionisation methods for mass spectrometric analyses of biological macromolecules", while Wüthrich received his half "for his development of nuclear magnetic resonance spectroscopy for determining the three-dimensional structure of biological macromolecules in solution". | * 2002: [http://nobelprize.org/nobel_prizes/chemistry/laureates/2002/index.html John B. Fenn, Koichi Tanaka, and Kurt Wüthrich] (Chemistry) "for the development of methods for identification and structure analyses of biological macromolecules". Fenn and Tanaka each were awarded one quarter of the prize "for their development of soft desorption ionisation methods for mass spectrometric analyses of biological macromolecules", while Wüthrich received his half "for his development of nuclear magnetic resonance spectroscopy for determining the three-dimensional structure of biological macromolecules in solution". | ||
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** [[Highest_impact_structures|Highest Impact Structures of All Time]]. | ** [[Highest_impact_structures|Highest Impact Structures of All Time]]. | ||
* 2012: [http://www.nobelprize.org/nobel_prizes/chemistry/laureates/2012/ Robert J. Lefkowitz and Brian K. Kobilka share the 2012 Nobel Prize in Chemistry] for work on G protein-coupled receptors that includes solving the first structures of a ligand-activated G protein-coupled receptor ([[2r4r]], [[2r4s]], & [[2rh1]] in 2007) and the first activated G protein-coupled receptor in complex with its G protein ([[3sn6]] in 2011). | ====2010-2019==== | ||
* 2012: [http://www.nobelprize.org/nobel_prizes/chemistry/laureates/2012/ Robert J. Lefkowitz and Brian K. Kobilka share the 2012 Nobel Prize in Chemistry] for work on [[G protein-coupled receptor |G protein-coupled receptors]] that includes solving the first structures of a ligand-activated G protein-coupled receptor ([[2r4r]], [[2r4s]], & [[2rh1]] in 2007) and the first activated G protein-coupled receptor in complex with its G protein ([[3sn6]] in 2011). | |||
** A detailed description of the laureates' body of work on this class of receptors with images is [http://www.nobelprize.org/nobel_prizes/chemistry/laureates/2012/popular-chemistryprize2012.pdf here]. | ** A detailed description of the laureates' body of work on this class of receptors with images is [http://www.nobelprize.org/nobel_prizes/chemistry/laureates/2012/popular-chemistryprize2012.pdf here]. | ||
** [[G protein-coupled receptor |G protein-coupled receptors]] in Proteopedia. | ** [[G protein-coupled receptor |G protein-coupled receptors]] in Proteopedia. | ||
* 2017: [https://www.nobelprize.org/prizes/chemistry/2017/summary/ Jacques Dubochet, Joachim Frank, and Richard Henderson share the 2017 Nobel Prize in Chemistry] "for developing cryo-electron microscopy for the high-resolution structure determination of biomolecules in solution." | |||
** [https://www.youtube.com/watch?v=026rzTXb1zw 5 min video] explaining their contributions. | |||
** Richard Henderson explains the history of cryo-EM in this [https://www.youtube.com/watch?v=L6U--sYUF9s 11 min video], and elaborates on single-particle cryo-EM in this [https://www.youtube.com/watch?v=j_sfs6uwWlc 14 min video]. | |||
====2020-2029==== | |||
* 2024: [https://www.nobelprize.org/prizes/chemistry/2024/summary/ David Baker, Demis Hassabis, and John M. Jumper share the 2024 Nobel Prize in Chemistry], Baker for "computational protein design", Hassabis and Jumper for "protein structure prediction" ([[AlphaFold]]). | |||
** [https://www.youtube.com/watch?v=cx7l9ZGFZkw 22 min video] explaining their contributions. | |||
** [https://www.youtube.com/watch?v=g96tXNwrYXc 9 min video] of David Baker explaining his protein design work. | |||
** [https://www.youtube.com/watch?v=SdxOouXsaxc 4 min video] of Demis Hassabis and John Jumper reacting to their Nobel Prize. | |||
** The [https://www.nobelprize.org/prizes/physics/2024/press-release/ 2024 Nobel Prize in Physics went to John J. Hopfield and Geoffrey E. Hinton] for machine learning with neural networks, technology that underlies the prizewinning work in Chemistry. | |||
==See Also== | ==See Also== | ||