3ejj: Difference between revisions

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-{{Seed}}
-[[Image:3ejj.jpg|left|200px]]
-<!--
+==Structure of M-CSF bound to the first three domains of FMS==
-The line below this paragraph, containing "STRUCTURE_3ejj", creates the "Structure Box" on the page.
+<StructureSection load='3ejj' size='340' side='right'caption='[[3ejj]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3ejj]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EJJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EJJ FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-{{STRUCTURE_3ejj|  PDB=3ejj  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ejj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ejj OCA], [https://pdbe.org/3ejj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ejj RCSB], [https://www.ebi.ac.uk/pdbsum/3ejj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ejj ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/CSF1_MOUSE CSF1_MOUSE] Note=A defect in Csf1 is the cause of osteopetrosis. Osteopetrotic mice (op/op) are severely deficient in mature macrophages and osteoclasts, display failed tooth eruption, and have a restricted capacity for bone remodeling.<ref>PMID:2188141</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/CSF1_MOUSE CSF1_MOUSE] Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ej/3ejj_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ejj ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Macrophage colony stimulating factor (M-CSF), through binding to its receptor FMS, a class III receptor tyrosine kinase (RTK), regulates the development and function of mononuclear phagocytes, and plays important roles in innate immunity, cancer and inflammation. We report a 2.4 A crystal structure of M-CSF bound to the first 3 domains (D1-D3) of FMS. The ligand binding mode of FMS is surprisingly different from KIT, another class III RTK, in which the major ligand-binding domain of FMS, D2, uses the CD and EF loops, but not the beta-sheet on the opposite side of the Ig domain as in KIT, to bind ligand. Calorimetric data indicate that M-CSF cannot dimerize FMS without receptor-receptor interactions mediated by FMS domains D4 and D5. Consistently, the structure contains only 1 FMS-D1-D3 molecule bound to a M-CSF dimer, due to a weak, hydrophilic M-CSF:FMS interface, and probably a conformational change of the M-CSF dimer in which binding to the second site is rendered unfavorable by FMS binding at the first site. The partial, intermediate complex suggests that FMS may be activated in two steps, with the initial engagement step distinct from the subsequent dimerization/activation step. Hence, the formation of signaling class III RTK complexes can be diverse, engaging various modes of ligand recognition and various mechanistic steps for dimerizing and activating receptors.
-===Structure of M-CSF bound to the first three domains of FMS===
+Structure of macrophage colony stimulating factor bound to FMS: diverse signaling assemblies of class III receptor tyrosine kinases.,Chen X, Liu H, Focia PJ, Shim AH, He X Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18267-72. Epub 2008 Nov 18. PMID:19017797<ref>PMID:19017797</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 3ejj" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_19017797}}, adds the Publication Abstract to the page
+*[[Colony-stimulating factor 3D structures|Colony-stimulating factor 3D structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 19017797 is the PubMed ID number.
+*[[Colony-stimulating factor receptor 3D structures|Colony-stimulating factor receptor 3D structures]]
--->
+== References ==
-{{ABSTRACT_PUBMED_19017797}}
+<references/>
+__TOC__
-==About this Structure==
+</StructureSection>
-EJJ is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EJJ OCA].
+[[Category: Large Structures]]
-==Reference==
-Structure of macrophage colony stimulating factor bound to FMS: diverse signaling assemblies of class III receptor tyrosine kinases., Chen X, Liu H, Focia PJ, Shim AH, He X, Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18267-72. Epub 2008 Nov 18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/19017797 19017797]
 [[Category: Mus musculus]]
-[[Category: Receptor protein-tyrosine kinase]]
+[[Category: Chen X]]
-[[Category: Chen, X.]]
+[[Category: Focia PJ]]
-[[Category: Focia, P J.]]
+[[Category: He X]]
-[[Category: He, X.]]
+[[Category: Liu H]]
-[[Category: Liu, H.]]
+[[Category: Shim A]]
-[[Category: Shim, A.]]
-[[Category: 4-helix bundle]]
-[[Category: Atp-binding]]
-[[Category: Cytokine]]
-[[Category: Cytokine/signaling protein complex]]
-[[Category: Glycoprotein]]
-[[Category: Growth factor-receptor complex]]
-[[Category: Immunoglobulin domain]]
-[[Category: Kinase]]
-[[Category: Membrane]]
-[[Category: Nucleotide-binding]]
-[[Category: Phosphoprotein]]
-[[Category: Proto-oncogene]]
-[[Category: Receptor]]
-[[Category: Receptor tyrosine kinase]]
-[[Category: Transferase]]
-[[Category: Transmembrane]]
-[[Category: Tyrosine-protein kinase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 10 15:07:03 2008''