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==The crystal structure of UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase (MPL) from Neisseria meningitides==
==The crystal structure of UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase (MPL) from Neisseria meningitides==
<StructureSection load='3eag' size='340' side='right' caption='[[3eag]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
<StructureSection load='3eag' size='340' side='right'caption='[[3eag]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3eag]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Neimb Neimb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EAG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3EAG FirstGlance]. <br>
<table><tr><td colspan='2'>[[3eag]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Neisseria_meningitidis_MC58 Neisseria meningitidis MC58]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EAG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EAG FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.55&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">mpl-2, mpl-1, NMB1145, NMB1183 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=122586 NEIMB])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3eag FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eag OCA], [https://pdbe.org/3eag PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3eag RCSB], [https://www.ebi.ac.uk/pdbsum/3eag PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3eag ProSAT], [https://www.topsan.org/Proteins/MCSG/3eag TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3eag FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eag OCA], [http://pdbe.org/3eag PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3eag RCSB], [http://www.ebi.ac.uk/pdbsum/3eag PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3eag ProSAT], [http://www.topsan.org/Proteins/MCSG/3eag TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q9JRY9_NEIMB Q9JRY9_NEIMB]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ea/3eag_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ea/3eag_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Neimb]]
[[Category: Large Structures]]
[[Category: Chang, C]]
[[Category: Neisseria meningitidis MC58]]
[[Category: Clancy, S]]
[[Category: Chang C]]
[[Category: Hendricks, R]]
[[Category: Clancy S]]
[[Category: Joachimiak, A]]
[[Category: Hendricks R]]
[[Category: Structural genomic]]
[[Category: Joachimiak A]]
[[Category: Atp-binding]]
[[Category: Ligase]]
[[Category: Mcsg]]
[[Category: Neisseria meningitidis mc58]]
[[Category: Nucleotide-binding]]
[[Category: PSI, Protein structure initiative]]
[[Category: Udp-n-acetylmuramate:l-alanyl-gamma-d-glutamyl-meso-diaminopimelate ligase]]

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