3e7s: Difference between revisions
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==Structure of bovine eNOS oxygenase domain with inhibitor AR-C95791== | ==Structure of bovine eNOS oxygenase domain with inhibitor AR-C95791== | ||
<StructureSection load='3e7s' size='340' side='right' caption='[[3e7s]], [[Resolution|resolution]] 2.50Å' scene=''> | <StructureSection load='3e7s' size='340' side='right'caption='[[3e7s]], [[Resolution|resolution]] 2.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3e7s]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[3e7s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E7S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3E7S FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AT2:ETHYL+4-[(4-METHYLPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE'>AT2</scene>, <scene name='pdbligand=CAS:S-(DIMETHYLARSENIC)CYSTEINE'>CAS</scene>, <scene name='pdbligand=HEC:HEME+C'>HEC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3e7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e7s OCA], [https://pdbe.org/3e7s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3e7s RCSB], [https://www.ebi.ac.uk/pdbsum/3e7s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3e7s ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/NOS3_BOVIN NOS3_BOVIN] Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e7/3e7s_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e7/3e7s_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/ | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3e7s ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 3e7s" style="background-color:#fffaf0;"></div> | |||
==See Also== | ==See Also== | ||
*[[Nitric Oxide Synthase|Nitric Oxide Synthase]] | *[[Nitric Oxide Synthase 3D structures|Nitric Oxide Synthase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Bos taurus]] | [[Category: Bos taurus]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Aberg | [[Category: Aberg A]] | ||
[[Category: Andersson | [[Category: Andersson G]] | ||
[[Category: Andrews | [[Category: Andrews G]] | ||
[[Category: Arvai | [[Category: Arvai AS]] | ||
[[Category: Cheshire | [[Category: Cheshire DR]] | ||
[[Category: Connolly | [[Category: Connolly S]] | ||
[[Category: Crane | [[Category: Crane BR]] | ||
[[Category: Garcin | [[Category: Garcin ED]] | ||
[[Category: Gensmantel | [[Category: Gensmantel NP]] | ||
[[Category: Getzoff | [[Category: Getzoff ED]] | ||
[[Category: Hamley | [[Category: Hamley PJ]] | ||
[[Category: Kroeger | [[Category: Kroeger MD]] | ||
[[Category: Mallinder | [[Category: Mallinder PR]] | ||
[[Category: Mete | [[Category: Mete A]] | ||
[[Category: Nicholls | [[Category: Nicholls DJ]] | ||
[[Category: Rosenfeld | [[Category: Rosenfeld RJ]] | ||
[[Category: St-Gallay | [[Category: St-Gallay SA]] | ||
[[Category: Stuehr | [[Category: Stuehr DJ]] | ||
[[Category: Tainer | [[Category: Tainer JA]] | ||
[[Category: Tinker | [[Category: Tinker AC]] | ||
[[Category: Wallace | [[Category: Wallace AV]] | ||