2k6u: Difference between revisions
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==The Solution Structure of a Conformationally Restricted Fully Active Derivative of the Human Relaxin-like Factor (RLF)== | ==The Solution Structure of a Conformationally Restricted Fully Active Derivative of the Human Relaxin-like Factor (RLF)== | ||
<StructureSection load='2k6u' size='340' side='right'caption='[[2k6u | <StructureSection load='2k6u' size='340' side='right'caption='[[2k6u]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2k6u]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K6U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K6U FirstGlance]. <br> | <table><tr><td colspan='2'>[[2k6u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K6U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K6U FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k6u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k6u OCA], [https://pdbe.org/2k6u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k6u RCSB], [https://www.ebi.ac.uk/pdbsum/2k6u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k6u ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k6u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k6u OCA], [https://pdbe.org/2k6u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k6u RCSB], [https://www.ebi.ac.uk/pdbsum/2k6u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k6u ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
[https://www.uniprot.org/uniprot/INSL3_HUMAN INSL3_HUMAN] Defects in INSL3 seems to be a cause of cryptorchidism (CRYPTO) [MIM:[https://omim.org/entry/219050 219050]; also known as impaired testicular descent. It is one of the most frequent congenital abnormalities in humans, involving 2-5% of male births. Cryptorchidism is associated with increased risk of infertility and testicular cancer. The frequency of INSL3 gene mutations as a cause of cryptorchidism is low.<ref>PMID:11095425</ref> <ref>PMID:11746019</ref> <ref>PMID:12601553</ref> | |||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/INSL3_HUMAN INSL3_HUMAN] Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor. | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Bullesbach | [[Category: Bullesbach EE]] | ||
[[Category: Hansen | [[Category: Hansen DF]] | ||
[[Category: Hass | [[Category: Hass MAS]] | ||
[[Category: Jensen | [[Category: Jensen MR]] | ||
[[Category: Kristensen | [[Category: Kristensen SM]] | ||
[[Category: Led | [[Category: Led JJ]] | ||
[[Category: Schwabe | [[Category: Schwabe C]] | ||