2k6u: Difference between revisions

<StructureSection load='2k6u' size='340' side='right'caption='[[2k6u]]' scene=''>

<table><tr><td colspan='2'>[[2k6u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K6U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K6U FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k6u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k6u OCA], [https://pdbe.org/2k6u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k6u RCSB], [https://www.ebi.ac.uk/pdbsum/2k6u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k6u ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/INSL3_HUMAN INSL3_HUMAN] Defects in INSL3 seems to be a cause of cryptorchidism (CRYPTO) [MIM:[https://omim.org/entry/219050 219050]; also known as impaired testicular descent. It is one of the most frequent congenital abnormalities in humans, involving 2-5% of male births. Cryptorchidism is associated with increased risk of infertility and testicular cancer. The frequency of INSL3 gene mutations as a cause of cryptorchidism is low.<ref>PMID:11095425</ref> <ref>PMID:11746019</ref> <ref>PMID:12601553</ref>  

[https://www.uniprot.org/uniprot/INSL3_HUMAN INSL3_HUMAN] Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor.

[[Category: Bullesbach EE]]

[[Category: Hansen DF]]

[[Category: Hass MAS]]

[[Category: Jensen MR]]

[[Category: Kristensen SM]]

[[Category: Led JJ]]

[[Category: Schwabe C]]