3dh9: Difference between revisions

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-{{Seed}}
-[[Image:3dh9.jpg|left|200px]]
-<!--
+==Crystal Structure of Drosophila Thioredoxin Reductase, wild-type==
-The line below this paragraph, containing "STRUCTURE_3dh9", creates the "Structure Box" on the page.
+<StructureSection load='3dh9' size='340' side='right'caption='[[3dh9]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3dh9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DH9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DH9 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
-{{STRUCTURE_3dh9|  PDB=3dh9  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dh9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dh9 OCA], [https://pdbe.org/3dh9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dh9 RCSB], [https://www.ebi.ac.uk/pdbsum/3dh9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dh9 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/TRXR1_DROME TRXR1_DROME] Thioredoxin system is a major player in glutathione metabolism, due to the demonstrated absence of a glutathione reductase. Functionally interacts with the Sod/Cat reactive oxidation species (ROS) defense system and thereby has a role in preadult development and life span. Lack of a glutathione reductase suggests antioxidant defense in Drosophila, and probably in related insects, differs fundamentally from that in other organisms.<ref>PMID:11158675</ref> <ref>PMID:11525742</ref> <ref>PMID:11796729</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dh/3dh9_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dh9 ConSurf].
+<div style="clear:both"></div>
-===Crystal Structure of Drosophila Thioredoxin Reductase, wild-type===
+==See Also==
+*[[Thioredoxin reductase 3D structures|Thioredoxin reductase 3D structures]]
+== References ==
-==About this Structure==
+<references/>
-DH9 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DH9 OCA].
+__TOC__
+</StructureSection>
 [[Category: Drosophila melanogaster]]
-[[Category: Thioredoxin-disulfide reductase]]
+[[Category: Large Structures]]
-[[Category: Eckenroth, B E.]]
+[[Category: Eckenroth BE]]
-[[Category: Everse, SJ.]]
+[[Category: Everse SJ]]
-[[Category: Hondal, R J.]]
+[[Category: Hondal RJ]]
-[[Category: Alternative initiation]]
-[[Category: Alternative splicing]]
-[[Category: Cytoplasm]]
-[[Category: Fad]]
-[[Category: Flavoprotein]]
-[[Category: Mitochondrion]]
-[[Category: Nadp]]
-[[Category: Oxidoreductase]]
-[[Category: Redox-active center]]
-[[Category: Rossmann]]
-[[Category: Transit peptide]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 17 11:22:12 2009''