3dcy: Difference between revisions

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-{{Seed}}
-[[Image:3dcy.jpg|left|200px]]
-<!--
+==Crystal Structure a TP53-induced glycolysis and apoptosis regulator protein from Homo sapiens.==
-The line below this paragraph, containing "STRUCTURE_3dcy", creates the "Structure Box" on the page.
+<StructureSection load='3dcy' size='340' side='right'caption='[[3dcy]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3dcy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DCY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DCY FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.748&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-{{STRUCTURE_3dcy|  PDB=3dcy  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dcy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dcy OCA], [https://pdbe.org/3dcy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dcy RCSB], [https://www.ebi.ac.uk/pdbsum/3dcy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dcy ProSAT], [https://www.topsan.org/Proteins/CESG/3dcy TOPSAN]</span></td></tr>
+</table>
-===Crystal Structure a TP53-induced glycolysis and apoptosis regulator protein from Homo sapiens.===
+== Function ==
+[https://www.uniprot.org/uniprot/TIGAR_HUMAN TIGAR_HUMAN] Fructose-bisphosphatase hydrolyzing fructose-2,6-bisphosphate as well as fructose-1,6-bisphosphate. Inhibits glycolysis by reducing cellular levels of fructose-2,6-bisphosphate. May protect cells against reactive oxygen species and against apoptosis induced by tp53.<ref>PMID:16839880</ref>
+== Evolutionary Conservation ==
-==About this Structure==
+[[Image:Consurf_key_small.gif|200px|right]]
-DCY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DCY OCA].
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dc/3dcy_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dcy ConSurf].
+<div style="clear:both"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Bingman, C A.]]
+[[Category: Bingman CA]]
-[[Category: CESG, Center for Eukaryotic Structural Genomics.]]
+[[Category: McCoy JG]]
-[[Category: Jr., G N.Phillips.]]
+[[Category: Phillips Jr GN]]
-[[Category: McCoy, J G.]]
+[[Category: Wesenberg GE]]
-[[Category: Wesenberg, G E.]]
-[[Category: C12orf5]]
-[[Category: Casp target]]
-[[Category: Center for eukaryotic structural genomic]]
-[[Category: Cesg]]
-[[Category: Isomerase]]
-[[Category: Omim 610775]]
-[[Category: Phosphoprotein]]
-[[Category: Protein structure initiative]]
-[[Category: Psi]]
-[[Category: Structural genomics medical relevance]]
-[[Category: Tigar]]
-[[Category: Tp53-induced glycolysis and apoptosis regulator]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 16 10:52:12 2008''