3dcy: Difference between revisions

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[[Image:3dcy.png|left|200px]]


{{STRUCTURE_3dcy|  PDB=3dcy  |  SCENE=  }}
==Crystal Structure a TP53-induced glycolysis and apoptosis regulator protein from Homo sapiens.==
 
<StructureSection load='3dcy' size='340' side='right'caption='[[3dcy]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
===Crystal Structure a TP53-induced glycolysis and apoptosis regulator protein from Homo sapiens.===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3dcy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DCY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DCY FirstGlance]. <br>
 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.748&#8491;</td></tr>
==About this Structure==
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
[[3dcy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DCY OCA].  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dcy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dcy OCA], [https://pdbe.org/3dcy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dcy RCSB], [https://www.ebi.ac.uk/pdbsum/3dcy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dcy ProSAT], [https://www.topsan.org/Proteins/CESG/3dcy TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TIGAR_HUMAN TIGAR_HUMAN] Fructose-bisphosphatase hydrolyzing fructose-2,6-bisphosphate as well as fructose-1,6-bisphosphate. Inhibits glycolysis by reducing cellular levels of fructose-2,6-bisphosphate. May protect cells against reactive oxygen species and against apoptosis induced by tp53.<ref>PMID:16839880</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dc/3dcy_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dcy ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Bingman, C A.]]
[[Category: Large Structures]]
[[Category: CESG, Center for Eukaryotic Structural Genomics.]]
[[Category: Bingman CA]]
[[Category: McCoy, J G.]]
[[Category: McCoy JG]]
[[Category: Phillips, G N.]]
[[Category: Phillips Jr GN]]
[[Category: Wesenberg, G E.]]
[[Category: Wesenberg GE]]
[[Category: Apoptosis regulator]]
[[Category: C12orf5]]
[[Category: Casp target]]
[[Category: Center for eukaryotic structural genomic]]
[[Category: Cesg]]
[[Category: Isomerase]]
[[Category: Omim 610775]]
[[Category: Phosphoprotein]]
[[Category: Protein structure initiative]]
[[Category: Psi]]
[[Category: Structural genomics medical relevance]]
[[Category: Tigar]]
[[Category: Tp53-induced glycolysis and apoptosis regulator]]

Latest revision as of 11:58, 30 October 2024

Crystal Structure a TP53-induced glycolysis and apoptosis regulator protein from Homo sapiens.Crystal Structure a TP53-induced glycolysis and apoptosis regulator protein from Homo sapiens.

Structural highlights

3dcy is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.748Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

TIGAR_HUMAN Fructose-bisphosphatase hydrolyzing fructose-2,6-bisphosphate as well as fructose-1,6-bisphosphate. Inhibits glycolysis by reducing cellular levels of fructose-2,6-bisphosphate. May protect cells against reactive oxygen species and against apoptosis induced by tp53.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Bensaad K, Tsuruta A, Selak MA, Vidal MN, Nakano K, Bartrons R, Gottlieb E, Vousden KH. TIGAR, a p53-inducible regulator of glycolysis and apoptosis. Cell. 2006 Jul 14;126(1):107-20. PMID:16839880 doi:http://dx.doi.org/10.1016/j.cell.2006.05.036

3dcy, resolution 1.75Å

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OCA
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