3dbq: Difference between revisions

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 ==Crystal structure of TTK kinase domain==
-<StructureSection load='3dbq' size='340' side='right' caption='[[3dbq]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
+<StructureSection load='3dbq' size='340' side='right'caption='[[3dbq]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[3dbq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DBQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DBQ FirstGlance]. <br>
+<table><tr><td colspan='2'>[[3dbq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DBQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DBQ FirstGlance]. <br>
-</td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TTK, MPS1L1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
-<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dual-specificity_kinase Dual-specificity kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.12.1 2.7.12.1] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3dbq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dbq OCA], [https://pdbe.org/3dbq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3dbq RCSB], [https://www.ebi.ac.uk/pdbsum/3dbq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3dbq ProSAT]</span></td></tr>
-<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dbq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dbq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3dbq RCSB], [http://www.ebi.ac.uk/pdbsum/3dbq PDBsum]</span></td></tr>
+</table>
-<table>
+== Function ==
+[https://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
 Check<jmol>
    <jmolCheckbox>
-     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/db/3dbq_consurf.spt"</scriptWhenChecked>
+     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/db/3dbq_consurf.spt"</scriptWhenChecked>
-     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
      <text>to colour the structure by Evolutionary Conservation</text>
    </jmolCheckbox>
-</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3dbq ConSurf].
 <div style="clear:both"></div>
 <div style="background-color:#fffaf0;">
@@ Line 25: / Line 27: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 3dbq" style="background-color:#fffaf0;"></div>
 ==See Also==
-*[[Dual specificity protein kinase|Dual specificity protein kinase]]
+*[[Dual specificity protein kinase 3D structures|Dual specificity protein kinase 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Dual-specificity kinase]]
 [[Category: Homo sapiens]]
-[[Category: Ahn, N.]]
+[[Category: Large Structures]]
-[[Category: Gao, Y F.]]
+[[Category: Ahn N]]
-[[Category: Lei, M.]]
+[[Category: Gao YF]]
-[[Category: Liu, X D.]]
+[[Category: Lei M]]
-[[Category: Old, W.]]
+[[Category: Liu XD]]
-[[Category: Resing, K.]]
+[[Category: Old W]]
-[[Category: Wang, F.]]
+[[Category: Resing K]]
-[[Category: Wang, W.]]
+[[Category: Wang F]]
-[[Category: Xu, Q B.]]
+[[Category: Wang W]]
-[[Category: Yang, Y T.]]
+[[Category: Xu QB]]
-[[Category: Zhu, S C.]]
+[[Category: Yang YT]]
-[[Category: Atp-binding]]
+[[Category: Zhu SC]]
-[[Category: Kinase]]
-[[Category: Kinase activation]]
-[[Category: Mps1 structure]]
-[[Category: Nucleotide-binding]]
-[[Category: Phosphoprotein]]
-[[Category: Phosphorylation]]
-[[Category: Serine/threonine-protein kinase]]
-[[Category: Transferase]]
-[[Category: Tyrosine-protein kinase]]