2vwm: Difference between revisions
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== | |||
<StructureSection load='2vwm' size='340' side='right' caption='[[2vwm]], [[Resolution|resolution]] 1.96Å' scene=''> | ==Aminopyrrolidine Factor Xa inhibitor== | ||
<StructureSection load='2vwm' size='340' side='right'caption='[[2vwm]], [[Resolution|resolution]] 1.96Å' scene=''> | |||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2vwm]] is a 4 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2vwm]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VWM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VWM FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LZI:(4R)-4-{[(5-CHLOROTHIOPHEN-2-YL)CARBONYL]AMINO}-N-(CYCLOPROPYLMETHYL)-1-(2-{[2-FLUORO-4-(2-OXOPYRIDIN-1(2H)-YL)PHENYL]AMINO}-2-OXOETHYL)-L-PROLINAMIDE'>LZI</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.96Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LZI:(4R)-4-{[(5-CHLOROTHIOPHEN-2-YL)CARBONYL]AMINO}-N-(CYCLOPROPYLMETHYL)-1-(2-{[2-FLUORO-4-(2-OXOPYRIDIN-1(2H)-YL)PHENYL]AMINO}-2-OXOETHYL)-L-PROLINAMIDE'>LZI</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vwm OCA], [https://pdbe.org/2vwm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vwm RCSB], [https://www.ebi.ac.uk/pdbsum/2vwm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vwm ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Disease == | == Disease == | ||
[ | [https://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN] Defects in F10 are the cause of factor X deficiency (FA10D) [MIM:[https://omim.org/entry/227600 227600]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.<ref>PMID:2790181</ref> <ref>PMID:1973167</ref> <ref>PMID:1985698</ref> <ref>PMID:7669671</ref> <ref>PMID:8529633</ref> <ref>PMID:7860069</ref> <ref>PMID:8845463</ref> <ref>PMID:8910490</ref> <ref>PMID:10468877</ref> <ref>PMID:10746568</ref> <ref>PMID:10739379</ref> <ref>PMID:11248282</ref> <ref>PMID:11728527</ref> <ref>PMID:12945883</ref> <ref>PMID:15650540</ref> <ref>PMID:17393015</ref> <ref>PMID:19135706</ref> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN] Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vw/2vwm_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vw/2vwm_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/ | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vwm ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 2vwm" style="background-color:#fffaf0;"></div> | |||
==See Also== | ==See Also== | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Banner | [[Category: Large Structures]] | ||
[[Category: Benz | [[Category: Banner DW]] | ||
[[Category: Blasco | [[Category: Benz JM]] | ||
[[Category: Decoret | [[Category: Blasco F]] | ||
[[Category: Groebke-Zbinden | [[Category: Decoret G]] | ||
[[Category: Haap | [[Category: Groebke-Zbinden K]] | ||
[[Category: Himber | [[Category: Haap W]] | ||
[[Category: Kuhn | [[Category: Himber J]] | ||
[[Category: Panday | [[Category: Kuhn B]] | ||
[[Category: Ricklin | [[Category: Panday N]] | ||
[[Category: Risch | [[Category: Ricklin F]] | ||
[[Category: Schlatter | [[Category: Risch P]] | ||
[[Category: Stahl | [[Category: Schlatter D]] | ||
[[Category: Unger | [[Category: Stahl M]] | ||
[[Category: Unger R]] | |||