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[[Image:2zca.png|left|200px]]


{{STRUCTURE_2zca|  PDB=2zca  |  SCENE=  }}
==Crystal Structure of TTHB189, a CRISPR-associated protein, Cse2 family from Thermus thermophilus HB8==
 
<StructureSection load='2zca' size='340' side='right'caption='[[2zca]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
===Crystal Structure of TTHB189, a CRISPR-associated protein, Cse2 family from Thermus thermophilus HB8===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2zca]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZCA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZCA FirstGlance]. <br>
 
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
==About this Structure==
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
[[2zca]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZCA OCA].  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zca FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zca OCA], [https://pdbe.org/2zca PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zca RCSB], [https://www.ebi.ac.uk/pdbsum/2zca PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zca ProSAT], [https://www.topsan.org/Proteins/RSGI/2zca TOPSAN]</span></td></tr>
 
</table>
==Reference==
== Function ==
<ref group="xtra">PMID:018798563</ref><references group="xtra"/>
[https://www.uniprot.org/uniprot/CSE2_THET8 CSE2_THET8] CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) (By similarity).
[[Category: Thermus thermophilus]]
== Evolutionary Conservation ==
[[Category: Agari, Y.]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: Kuramitsu, S.]]
Check<jmol>
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
  <jmolCheckbox>
[[Category: Shinkai, A.]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zc/2zca_consurf.spt"</scriptWhenChecked>
[[Category: Yokoyama, S.]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
[[Category: Crispr]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: Cse2]]
  </jmolCheckbox>
[[Category: National project on protein structural and functional analyse]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zca ConSurf].
[[Category: Nppsfa]]
<div style="clear:both"></div>
[[Category: Riken structural genomics/proteomics initiative]]
__TOC__
[[Category: Rsgi]]
</StructureSection>
[[Category: Structural genomic]]
[[Category: Large Structures]]
[[Category: Thermus thermophilus]]
[[Category: Thermus thermophilus]]
[[Category: Unknown function]]
[[Category: Agari Y]]
[[Category: Kuramitsu S]]
[[Category: Shinkai A]]
[[Category: Yokoyama S]]

Latest revision as of 04:33, 21 November 2024

Crystal Structure of TTHB189, a CRISPR-associated protein, Cse2 family from Thermus thermophilus HB8Crystal Structure of TTHB189, a CRISPR-associated protein, Cse2 family from Thermus thermophilus HB8

Structural highlights

2zca is a 2 chain structure with sequence from Thermus thermophilus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.8Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

CSE2_THET8 CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

2zca, resolution 1.80Å

Drag the structure with the mouse to rotate

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OCA
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