2rmx: Difference between revisions

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-[[Image:2rmx.png|left|200px]]
-{{STRUCTURE_2rmx|  PDB=2rmx  |  SCENE=  }}
+==Solution structure of the SHP-1 C-terminal SH2 domain complexed with a tyrosine-phosphorylated peptide from NKG2A==
+<StructureSection load='2rmx' size='340' side='right'caption='[[2rmx]]' scene=''>
-===Solution structure of the SHP-1 C-terminal SH2 domain complexed with a tyrosine-phosphorylated peptide from NKG2A===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2rmx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RMX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RMX FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
-==About this Structure==
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
-[[2rmx]] is a 2 chain structure of [[Proten tyrosine phosphatase]] and [[Tyrosine phosphatase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RMX OCA].
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rmx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rmx OCA], [https://pdbe.org/2rmx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rmx RCSB], [https://www.ebi.ac.uk/pdbsum/2rmx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rmx ProSAT], [https://www.topsan.org/Proteins/RSGI/2rmx TOPSAN]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PTN6_HUMAN PTN6_HUMAN] Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.<ref>PMID:11266449</ref>
 ==See Also==
-*[[Proten tyrosine phosphatase|Proten tyrosine phosphatase]]
+*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
-*[[Tyrosine phosphatase|Tyrosine phosphatase]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Protein-tyrosine-phosphatase]]
+[[Category: Large Structures]]
-[[Category: Inoue, M.]]
+[[Category: Inoue M]]
-[[Category: Kasai, T.]]
+[[Category: Kasai T]]
-[[Category: Kigawa, T.]]
+[[Category: Kigawa T]]
-[[Category: Koshiba, S.]]
+[[Category: Koshiba S]]
-[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
+[[Category: Yokoyama S]]
-[[Category: Yokoyama, S.]]
-[[Category: Glycoprotein]]
-[[Category: Hydrolase]]
-[[Category: Lectin]]
-[[Category: Membrane]]
-[[Category: National project on protein structural and functional analyse]]
-[[Category: Nppsfa]]
-[[Category: Nucleus]]
-[[Category: Phosphoprotein]]
-[[Category: Phosphorylated peptide recognition]]
-[[Category: Phosphotyrosine binding domain]]
-[[Category: Protein phosphatase]]
-[[Category: Protein-peptide complex]]
-[[Category: Receptor]]
-[[Category: Riken structural genomics/proteomics initiative]]
-[[Category: Rsgi]]
-[[Category: Sh2 domain]]
-[[Category: Signal transduction]]
-[[Category: Signal-anchor]]
-[[Category: Signaling protein]]
-[[Category: Structural genomic]]
-[[Category: Transmembrane]]