3cl4: Difference between revisions
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==Crystal structure of bovine coronavirus hemagglutinin-esterase== | ==Crystal structure of bovine coronavirus hemagglutinin-esterase== | ||
<StructureSection load='3cl4' size='340' side='right' caption='[[3cl4]], [[Resolution|resolution]] 2.10Å' scene=''> | <StructureSection load='3cl4' size='340' side='right'caption='[[3cl4]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3cl4]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[3cl4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bovine_coronavirus_Mebus Bovine coronavirus Mebus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CL4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CL4 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |||
<tr id=' | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cl4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cl4 OCA], [https://pdbe.org/3cl4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cl4 RCSB], [https://www.ebi.ac.uk/pdbsum/3cl4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cl4 ProSAT]</span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/HEMA_CVBM HEMA_CVBM] Structural protein that makes short spikes at the surface of the virus. Contains receptor binding and receptor-destroying activities. Mediates de-O-acetylation of N-acetyl-9-O-acetylneuraminic acid, which is probably the receptor determinant recognized by the virus on the surface of erythrocytes and susceptible cells. This receptor-destroying activity is important for virus release as it probably helps preventing self-aggregation and ensures the efficient spread of the progeny virus from cell to cell. May serve as a secondary viral attachment protein for initiating infection, the spike protein being the major one. Seems to be a 'luxury' protein that is not absolutely necessary for virus infection in culture. However, its presence in the virus may alter its pathogenicity. May become a target for both the humoral and the cellular branches of the immune system. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cl/3cl4_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cl/3cl4_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/ | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
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==See Also== | ==See Also== | ||
*[[Hemagglutinin-esterase|Hemagglutinin-esterase]] | *[[Hemagglutinin-esterase 3D structures|Hemagglutinin-esterase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Bovine coronavirus]] | [[Category: Bovine coronavirus Mebus]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Huizinga EG]] | |||
[[Category: Huizinga | [[Category: Langereis MA]] | ||
[[Category: Langereis | [[Category: Zeng QH]] | ||
[[Category: De Groot RJ]] | |||
[[Category: Zeng | [[Category: Van Vliet ALW]] | ||
[[Category: | |||
[[Category: | |||