2uvs: Difference between revisions

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-{{Seed}}
-[[Image:2uvs.png|left|200px]]
-<!--
+==High Resolution Solid-state NMR structure of Kaliotoxin==
-The line below this paragraph, containing "STRUCTURE_2uvs", creates the "Structure Box" on the page.
+<StructureSection load='2uvs' size='340' side='right'caption='[[2uvs]]' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2uvs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Androctonus_mauritanicus Androctonus mauritanicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UVS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2UVS FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solid-state NMR, 20 models</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2uvs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uvs OCA], [https://pdbe.org/2uvs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2uvs RCSB], [https://www.ebi.ac.uk/pdbsum/2uvs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2uvs ProSAT]</span></td></tr>
-{{STRUCTURE_2uvs|  PDB=2uvs  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/KAX31_ANDMA KAX31_ANDMA] Potent inhibitor of large conductance calcium-activated potassium channels (BK-Ca). Also binds to the dendrotoxin sensitive voltage-dependent potassium channel. It appears to block channel activity by a simple bimolecular inhibition process. Induces a transient period of fast flickering in the channel openings, followed by an almost complete blockade of the channel. Its binding affinity to rat brain synaptosomes is 5-fold higher than this of KTX-3. Binding of the toxin to the channel is associated with significant structural rearrangements in both molecules.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uv/2uvs_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2uvs ConSurf].
+<div style="clear:both"></div>
-===HIGH RESOLUTION SOLID-STATE NMR STRUCTURE OF KALIOTOXIN===
+==See Also==
+*[[Potassium channel toxin 3D structures|Potassium channel toxin 3D structures]]
+__TOC__
-==About this Structure==
+</StructureSection>
-UVS is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Androctonus_mauretanicus_mauretanicus Androctonus mauretanicus mauretanicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UVS OCA].
+[[Category: Androctonus mauritanicus]]
-[[Category: Androctonus mauretanicus mauretanicus]]
+[[Category: Large Structures]]
-[[Category: Baldus, M.]]
+[[Category: Baldus M]]
-[[Category: Becker, S.]]
+[[Category: Becker S]]
-[[Category: Korukottu, J.]]
+[[Category: Korukottu J]]
-[[Category: Lange, A.]]
+[[Category: Lange A]]
-[[Category: Pongs, O.]]
+[[Category: Pongs O]]
-[[Category: Schneider, R.]]
+[[Category: Schneider R]]
-[[Category: Vijayan, V.]]
+[[Category: Vijayan V]]
-[[Category: Zweckstetter, M.]]
+[[Category: Zweckstetter M]]
-[[Category: Amidation]]
-[[Category: Ionic channel inhibitor]]
-[[Category: Neurotoxin]]
-[[Category: Potassium channel inhibitor]]
-[[Category: Toxin]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 23:48:16 2009''