2uvs: Difference between revisions
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==High Resolution Solid-state NMR structure of Kaliotoxin== | |||
<StructureSection load='2uvs' size='340' side='right'caption='[[2uvs]]' scene=''> | |||
=== | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2uvs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Androctonus_mauritanicus Androctonus mauritanicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UVS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2UVS FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solid-state NMR, 20 models</td></tr> | |||
== | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2uvs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2uvs OCA], [https://pdbe.org/2uvs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2uvs RCSB], [https://www.ebi.ac.uk/pdbsum/2uvs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2uvs ProSAT]</span></td></tr> | ||
[[2uvs]] is a 1 chain structure with sequence from [ | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/KAX31_ANDMA KAX31_ANDMA] Potent inhibitor of large conductance calcium-activated potassium channels (BK-Ca). Also binds to the dendrotoxin sensitive voltage-dependent potassium channel. It appears to block channel activity by a simple bimolecular inhibition process. Induces a transient period of fast flickering in the channel openings, followed by an almost complete blockade of the channel. Its binding affinity to rat brain synaptosomes is 5-fold higher than this of KTX-3. Binding of the toxin to the channel is associated with significant structural rearrangements in both molecules. | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uv/2uvs_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2uvs ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | ==See Also== | ||
*[[Potassium channel toxin|Potassium channel toxin]] | *[[Potassium channel toxin 3D structures|Potassium channel toxin 3D structures]] | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Androctonus mauritanicus]] | [[Category: Androctonus mauritanicus]] | ||
[[Category: Baldus | [[Category: Large Structures]] | ||
[[Category: Becker | [[Category: Baldus M]] | ||
[[Category: Korukottu | [[Category: Becker S]] | ||
[[Category: Lange | [[Category: Korukottu J]] | ||
[[Category: Pongs | [[Category: Lange A]] | ||
[[Category: Schneider | [[Category: Pongs O]] | ||
[[Category: Vijayan | [[Category: Schneider R]] | ||
[[Category: Zweckstetter | [[Category: Vijayan V]] | ||
[[Category: Zweckstetter M]] | |||