3ca7: Difference between revisions

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-{{Seed}}
-[[Image:3ca7.png|left|200px]]
-<!--
+==High Resolution Crystal Structure of the EGF domain of Spitz==
-The line below this paragraph, containing "STRUCTURE_3ca7", creates the "Structure Box" on the page.
+<StructureSection load='3ca7' size='340' side='right'caption='[[3ca7]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3ca7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CA7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CA7 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ca7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ca7 OCA], [https://pdbe.org/3ca7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ca7 RCSB], [https://www.ebi.ac.uk/pdbsum/3ca7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ca7 ProSAT]</span></td></tr>
-{{STRUCTURE_3ca7|  PDB=3ca7  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/SPITZ_DROME SPITZ_DROME] Ligand for the EGF receptor (Gurken). Involved in a number of unrelated developmental choices, for example, dorsal-ventral axis formation, glial migration, sensory organ determination, and muscle development. It is required for photoreceptor determination.<ref>PMID:7833286</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ca/3ca7_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ca7 ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Members of the epidermal growth factor receptor (EGFR) or ErbB/HER family and their activating ligands are essential regulators of diverse developmental processes. Inappropriate activation of these receptors is a key feature of many human cancers, and its reversal is an important clinical goal. A natural secreted antagonist of EGFR signalling, called Argos, was identified in Drosophila. We showed previously that Argos functions by directly binding (and sequestering) growth factor ligands that activate EGFR. Here we describe the 1.6-A resolution crystal structure of Argos bound to an EGFR ligand. Contrary to expectations, Argos contains no EGF-like domain. Instead, a trio of closely related domains (resembling a three-finger toxin fold) form a clamp-like structure around the bound EGF ligand. Although structurally unrelated to the receptor, Argos mimics EGFR by using a bipartite binding surface to entrap EGF. The individual Argos domains share unexpected structural similarities with the extracellular ligand-binding regions of transforming growth factor-beta family receptors. The three-domain clamp of Argos also resembles the urokinase-type plasminogen activator (uPA) receptor, which uses a similar mechanism to engulf the EGF-like module of uPA. Our results indicate that undiscovered mammalian counterparts of Argos may exist among other poorly characterized structural homologues. In addition, the structures presented here define requirements for the design of artificial EGF-sequestering proteins that would be valuable anti-cancer therapeutics.
-===High Resolution Crystal Structure of the EGF domain of Spitz===
+Structural basis for EGFR ligand sequestration by Argos.,Klein DE, Stayrook SE, Shi F, Narayan K, Lemmon MA Nature. 2008 Jun 26;453(7199):1271-5. Epub 2008 May 25. PMID:18500331<ref>PMID:18500331</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-<!--
+</div>
-The line below this paragraph, {{ABSTRACT_PUBMED_18500331}}, adds the Publication Abstract to the page
+<div class="pdbe-citations 3ca7" style="background-color:#fffaf0;"></div>
-(as it appears on PubMed at http://www.pubmed.gov), where 18500331 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_18500331}}
+__TOC__
+</StructureSection>
-==About this Structure==
-CA7 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CA7 OCA].
-==Reference==
-<ref group="xtra">PMID:18500331</ref><references group="xtra"/>
 [[Category: Drosophila melanogaster]]
-[[Category: Klein, D E.]]
+[[Category: Large Structures]]
-[[Category: Lemmon, M A.]]
+[[Category: Klein DE]]
-[[Category: Stayrook, S E.]]
+[[Category: Lemmon MA]]
-[[Category: Argo]]
+[[Category: Stayrook SE]]
-[[Category: Developmental protein]]
-[[Category: Differentiation]]
-[[Category: Egf]]
-[[Category: Egf-like domain]]
-[[Category: Endoplasmic reticulum]]
-[[Category: Glycoprotein]]
-[[Category: Golgi apparatus]]
-[[Category: Hormone/signaling protein complex]]
-[[Category: Membrane]]
-[[Category: Neurogenesis]]
-[[Category: Spitz]]
-[[Category: Transmembrane]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 22 11:21:02 2009''