2vnn: Difference between revisions

 

==Human BACE-1 in complex with 7-ethyl-N-((1S,2R)-2-hydroxy-1-(phenylmethyl)-3-(((3-(trifluoromethyl)phenyl)methyl)amino)propyl)-1- methyl-3,4-dihydro-1H-(1,2,5)thiadiazepino(3,4,5-hi)indole-9- carboxamide 2,2-dioxide==

<StructureSection load='2vnn' size='340' side='right'caption='[[2vnn]], [[Resolution|resolution]] 1.87&Aring;' scene=''>

<table><tr><td colspan='2'>[[2vnn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VNN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VNN FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.87&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CM7:N-[(1S,2R)-1-BENZYL-2-HYDROXY-3-{[3-(TRIFLUOROMETHYL)BENZYL]AMINO}PROPYL]-7-ETHYL-1-METHYL-3,4-DIHYDRO-1H-[1,2,5]THIADIAZEPINO[3,4,5-HI]INDOLE-9-CARBOXAMIDE+2,2-DIOXIDE'>CM7</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vnn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vnn OCA], [https://pdbe.org/2vnn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vnn RCSB], [https://www.ebi.ac.uk/pdbsum/2vnn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vnn ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>  

     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vn/2vnn_consurf.spt"</scriptWhenChecked>

     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>

*[[Beta secretase 3D structures|Beta secretase 3D structures]]

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Charrier N]]

[[Category: Clarke B]]

[[Category: Cutler L]]

[[Category: Demont E]]

[[Category: Dingwall C]]

[[Category: Dunsdon R]]

[[Category: East P]]

[[Category: Hawkins J]]

[[Category: Howes C]]

[[Category: Hussain I]]

[[Category: Jeffrey P]]

[[Category: Maile G]]

[[Category: Matico R]]

[[Category: Mosley J]]

[[Category: Naylor A]]

[[Category: OBrien A]]

[[Category: Redshaw S]]

[[Category: Rowland P]]

[[Category: Smith KJ]]

[[Category: Soleil V]]

[[Category: Sweitzer S]]

[[Category: Theobald P]]

[[Category: Vesey D]]

[[Category: Walter DS]]

[[Category: Wayne G]]