DNA: Difference between revisions
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|BAMBEDDOI=10.1002/bmb.20566 | |BAMBEDDOI=10.1002/bmb.20566 | ||
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<StructureSection load='B-DNA.pdb' size='450' side='right' scene='DNA/B-dna/7' caption='The double-helical structure of B-DNA, shown as ball-and-stick (colored by element {{Template:ColorKey_Element_C}} {{Template:ColorKey_Element_H}} {{Template:ColorKey_Element_O}} {{Template:ColorKey_Element_N}} {{Template:ColorKey_Element_P}}) with the helical conformation of the sugar-phosphate shown as orange ribbon, the planes of the nucleobases in orange as well.'> | <StructureSection load='B-DNA.pdb' size='450' side='right' scene='DNA/B-dna/7' caption='The double-helical structure of B-DNA, shown as ball-and-stick (colored by element {{Template:ColorKey_Element_C}} {{Template:ColorKey_Element_H}} {{Template:ColorKey_Element_O}} {{Template:ColorKey_Element_N}} {{Template:ColorKey_Element_P}}) with the helical conformation of the sugar-phosphate shown as orange ribbon, and the planes of the nucleobases (drag down in the viewer to see them) in orange as well.'> | ||
'''Deoxyribonucleic acid''' or '''DNA''' is a molecule which is the carrier of genetic information in nearly all the living organisms. It contains the biological instructions for the development, survival and reproduction of organisms. | '''Deoxyribonucleic acid''' or '''DNA''' is a molecule which is the carrier of genetic information in nearly all the living organisms. It contains the biological instructions for the development, survival and reproduction of organisms. | ||
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=== Grooves === | === Grooves === | ||
In a <scene name='DNA/Bdnasf/1'>DNA double helix</scene> the <scene name='DNA/Angled_gylcosidic/5'>beta-glycosyl bonds</scene> of bases which are paired <scene name='DNA/Angled_gylcosidic/7'>do not lie opposite</scene> to each other but are positioned at an angle. This results in unequally spaced sugar-phosphate backbones and gives rise to two grooves: the | In a <scene name='DNA/Bdnasf/1'>DNA double helix</scene> the <scene name='DNA/Angled_gylcosidic/5'>beta-glycosyl bonds</scene> of bases which are paired <scene name='DNA/Angled_gylcosidic/7'>do not lie opposite</scene> to each other but are positioned at an angle. | ||
[[Image:DNA grooves.png|200px]] | |||
This results in unequally spaced sugar-phosphate backbones and gives rise to <scene name='10/100853/Grooves/2'>two grooves</scene>: the | |||
<scene name='DNA/Major_groove/2'>major groove</scene> and the <scene name='DNA/Major_groove/7'>minor groove</scene> of different width and depth. The <scene name='DNA/Major_groove/8'>oxygen atoms of the furanose rings</scene> are on the surface of the minor groove, and the major groove is on the opposite side. The floor or surface of major groove is filled with the <scene name='DNA/Major_floor/2'>atoms of the bases</scene>. The larger size of major groove allows for the binding of DNA specific proteins.<ref name="Saenger"> Saenger, Wolfram (1984). ''Principles of Nucleic Acid Structure '' (1st ed). Springer-Verlag. pp. 398. ISBN 0-12-645750-6.</ref><ref name='Watson'> Watson, James D, Nancy H. Hopkins, Jeffrey W. Roberts, Joan Argetsinger Steitz, Alan M.Weiner ''Molecular Biology of Gene'' (4th ed.). The Benjamin/Cummings Publishing Company Inc.pp. 239-249. ISBN 0-8053-9612-8</ref> | <scene name='DNA/Major_groove/2'>major groove</scene> and the <scene name='DNA/Major_groove/7'>minor groove</scene> of different width and depth. The <scene name='DNA/Major_groove/8'>oxygen atoms of the furanose rings</scene> are on the surface of the minor groove, and the major groove is on the opposite side. The floor or surface of major groove is filled with the <scene name='DNA/Major_floor/2'>atoms of the bases</scene>. The larger size of major groove allows for the binding of DNA specific proteins.<ref name="Saenger"> Saenger, Wolfram (1984). ''Principles of Nucleic Acid Structure '' (1st ed). Springer-Verlag. pp. 398. ISBN 0-12-645750-6.</ref><ref name='Watson'> Watson, James D, Nancy H. Hopkins, Jeffrey W. Roberts, Joan Argetsinger Steitz, Alan M.Weiner ''Molecular Biology of Gene'' (4th ed.). The Benjamin/Cummings Publishing Company Inc.pp. 239-249. ISBN 0-8053-9612-8</ref> | ||
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===Proteopedia Articles=== | ===Proteopedia Articles=== | ||
*[[Forms of DNA]] | *[[Forms of DNA]] | ||
* Kinks vs. Bends in DNA are discussed in [[Lac repressor]]. | |||
* [[User:Karsten Theis/DNA bulges|DNA bulges]] occur when a nucleotide is inserted in one strand but not the other, causing an interruption in base pairing. | |||
*[[1ply]] | *[[1ply]] | ||
*[[DNA Replication, Repair, and Recombination]] - Articles in Proteopedia concerning DNA Replication, Repair, and/or Recombination | *[[DNA Replication, Repair, and Recombination]] - Articles in Proteopedia concerning DNA Replication, Repair, and/or Recombination | ||