2ra4: Difference between revisions

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-{{Seed}}
-[[Image:2ra4.png|left|200px]]
-<!--
+==Crystal Structure of Human Monocyte Chemoattractant Protein 4 (MCP-4/CCL13)==
-The line below this paragraph, containing "STRUCTURE_2ra4", creates the "Structure Box" on the page.
+<StructureSection load='2ra4' size='340' side='right'caption='[[2ra4]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2ra4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RA4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RA4 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TFA:TRIFLUOROACETIC+ACID'>TFA</scene></td></tr>
-{{STRUCTURE_2ra4|  PDB=2ra4  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ra4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ra4 OCA], [https://pdbe.org/2ra4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ra4 RCSB], [https://www.ebi.ac.uk/pdbsum/2ra4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ra4 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CCL13_HUMAN CCL13_HUMAN] Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of allergic and non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically exposed to exogenous pathogens.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ra/2ra4_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ra4 ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Monocyte chemoattractant proteins (MCPs) belong to the CC chemokine family and are involved in many (patho)physiological processes characterized by mononuclear cell infiltration, including tissue remodeling, atherosclerosis and cancer metastasis. Here, the crystal structure of human monocyte chemoattractant protein 4 (MCP-4) refined at 1.70 A resolution is reported with crystallographic values R = 0.180 and R free = 0.212. The overall MCP-4 fold reveals the typical tertiary features of the CC chemokine family. A central three-stranded antiparallel beta-sheet is C-terminally flanked by an overlaying alpha-helix, while the N-terminal part of the molecule forms an extended loop that is anchored to the rest of the molecule via two disulfide bridges, Cys11-Cys35 and Cys12-Cys51. The crystal packing suggests the existence of MCP-4 dimers with a dimerization interface similar to those previously reported for the X-ray structures of MCP-1 and MCP-2.
-===Crystal Structure of Human Monocyte Chemoattractant Protein 4 (MCP-4/CCL13)===
+Structure of human monocyte chemoattractant protein 4 (MCP-4/CCL13).,Barinka C, Prahl A, Lubkowski J Acta Crystallogr D Biol Crystallogr. 2008 Mar;64(Pt 3):273-8. Epub 2008, Feb 20. PMID:18323622<ref>PMID:18323622</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 2ra4" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_18323622}}, adds the Publication Abstract to the page
+*[[Monocyte chemoattractant protein|Monocyte chemoattractant protein]]
-(as it appears on PubMed at http://www.pubmed.gov), where 18323622 is the PubMed ID number.
+*[[Multiple sclerosis|Multiple sclerosis]]
--->
+== References ==
-{{ABSTRACT_PUBMED_18323622}}
+<references/>
+__TOC__
-==About this Structure==
+</StructureSection>
-RA4 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RA4 OCA].
-==Reference==
-<ref group="xtra">PMID:18323622</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Barinka, C.]]
+[[Category: Large Structures]]
-[[Category: Lubkowski, J.]]
+[[Category: Barinka C]]
-[[Category: Cc chemokine family]]
+[[Category: Lubkowski J]]
-[[Category: Ccl13]]
-[[Category: Chemotaxis]]
-[[Category: Cytokine]]
-[[Category: Inflammatory response]]
-[[Category: Mcp-4]]
-[[Category: Monocyte]]
-[[Category: Polymorphism]]
-[[Category: Pyrrolidone carboxylic acid]]
-[[Category: Secreted]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 06:42:33 2009''