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[[Image:2otp.jpg|left|200px]]


{{Structure
==Crystal Structure of Immunoglobulin-Like Transcript 1 (ILT1/LIR7/LILRA2)==
|PDB= 2otp |SIZE=350|CAPTION= <scene name='initialview01'>2otp</scene>, resolution 2.60&Aring;
<StructureSection load='2otp' size='340' side='right'caption='[[2otp]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND=  
<table><tr><td colspan='2'>[[2otp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OTP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OTP FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
|GENE= LILRA2, ILT1, LIR7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2otp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2otp OCA], [https://pdbe.org/2otp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2otp RCSB], [https://www.ebi.ac.uk/pdbsum/2otp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2otp ProSAT]</span></td></tr>
}}
</table>
== Function ==
[https://www.uniprot.org/uniprot/LIRA2_HUMAN LIRA2_HUMAN] Does not bind class I MHC antigens.<ref>PMID:19230061</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ot/2otp_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2otp ConSurf].
<div style="clear:both"></div>


'''Crystal Structure of Immunoglobulin-Like Transcript 1 (ILT1/LIR7/LILRA2)'''
==See Also==
 
*[[Leukocyte immunoglobulin-like receptor|Leukocyte immunoglobulin-like receptor]]
 
== References ==
==About this Structure==
<references/>
2OTP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OTP OCA].
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Chen, Y.]]
[[Category: Chen Y]]
[[Category: Gao, F.]]
[[Category: Gao F]]
[[Category: Gao, G F.]]
[[Category: Gao GF]]
[[Category: Liu, Y.]]
[[Category: Liu Y]]
[[Category: Peng, H.]]
[[Category: Peng H]]
[[Category: activating receptor]]
[[Category: crystal structure]]
[[Category: dimer]]
[[Category: domain swapping]]
[[Category: ilt1]]
[[Category: immune system]]
[[Category: monomer]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:04:20 2008''

Latest revision as of 11:25, 30 October 2024

Crystal Structure of Immunoglobulin-Like Transcript 1 (ILT1/LIR7/LILRA2)Crystal Structure of Immunoglobulin-Like Transcript 1 (ILT1/LIR7/LILRA2)

Structural highlights

2otp is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.6Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

LIRA2_HUMAN Does not bind class I MHC antigens.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Chen Y, Gao F, Chu F, Peng H, Zong L, Liu Y, Tien P, Gao GF. Crystal structure of myeloid cell activating receptor leukocyte Ig-like receptor A2 (LILRA2/ILT1/LIR-7) domain swapped dimer: molecular basis for its non-binding to MHC complexes. J Mol Biol. 2009 Feb 27;386(3):841-53. PMID:19230061

2otp, resolution 2.60Å

Drag the structure with the mouse to rotate

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OCA
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