2gjm: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-[[Image:2gjm.gif|left|200px]]<br /><applet load="2gjm" size="350" color="white" frame="true" align="right" spinBox="true"
-caption="2gjm, resolution 2.75&Aring;" />
-'''Crystal structure of Buffalo lactoperoxidase at 2.75A resolution'''<br />
-==About this Structure==
+==Crystal structure of Buffalo lactoperoxidase at 2.75A resolution==
-GJM is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Bubalus_bubalis Bubalus bubalis] with <scene name='pdbligand=SCN:'>SCN</scene>, <scene name='pdbligand=CO3:'>CO3</scene>, <scene name='pdbligand=CA:'>CA</scene>, <scene name='pdbligand=IOD:'>IOD</scene> and <scene name='pdbligand=HEM:'>HEM</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Peroxidase Peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.7 1.11.1.7] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GJM OCA].
+<StructureSection load='2gjm' size='340' side='right'caption='[[2gjm]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2gjm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bubalus_bubalis Bubalus bubalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GJM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GJM FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gjm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gjm OCA], [https://pdbe.org/2gjm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gjm RCSB], [https://www.ebi.ac.uk/pdbsum/2gjm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gjm ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PERL_BUBBU PERL_BUBBU] Antimicrobial agent which utilizes hydrogen peroxide and thiocyanate (SCN) to generate the antimicrobial substance hypothiocyanous acid (HOSCN). May protect the udder from infection and promote growth in newborn calves. Inhibits growth of the following bacterial species: E.coli, K.pneumoniae, P.aeruginosa, S.sonnei, S.saphrophyticus, S.epidermidis, and S.dysenteriae.<ref>PMID:12071645</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gj/2gjm_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gjm ConSurf].
+<div style="clear:both"></div>
+==See Also==
+*[[Lactoperoxidase|Lactoperoxidase]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Bubalus bubalis]]
-[[Category: Peroxidase]]
+[[Category: Large Structures]]
-[[Category: Protein complex]]
+[[Category: Ethayathulla AS]]
-[[Category: Ethayathulla, A.S.]]
+[[Category: Sharma S]]
-[[Category: Sharma, S.]]
+[[Category: Sheikh IA]]
-[[Category: Sheikh, I.A.]]
+[[Category: Singh AK]]
-[[Category: Singh, A.K.]]
+[[Category: Singh N]]
-[[Category: Singh, N.]]
+[[Category: Singh TP]]
-[[Category: Singh, T.P.]]
-[[Category: CA]]
-[[Category: CO3]]
-[[Category: HEM]]
-[[Category: IOD]]
-[[Category: SCN]]
-[[Category: buffalo]]
-[[Category: crystal structure]]
-[[Category: lactoperoxidase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jan 29 20:01:20 2008''