2jmc: Difference between revisions

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-[[Image:2jmc.png|left|200px]]
-{{STRUCTURE_2jmc|  PDB=2jmc  |  SCENE=  }}
+==Chimer between Spc-SH3 and P41==
+<StructureSection load='2jmc' size='340' side='right'caption='[[2jmc]]' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2jmc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JMC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JMC FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jmc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jmc OCA], [https://pdbe.org/2jmc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jmc RCSB], [https://www.ebi.ac.uk/pdbsum/2jmc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jmc ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/SPTN1_CHICK SPTN1_CHICK] Morphologically, spectrin-like proteins appear to be related to spectrin, showing a flexible rod-like structure. They can bind actin but seem to differ in their calmodulin-binding activity. In nonerythroid tissues, spectrins, in association with some other proteins, may play an important role in membrane organization.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jm/2jmc_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jmc ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Here we present the high-resolution NMR structure of a chimera (SPCp41) between alpha-spectrin SH3 domain and the decapeptide p41. The tertiary structure mimics perfectly the interactions typically found in SH3-peptide complexes and is remarkably similar to that of the complex between the separate Spc-SH3 domain and ligand p41. Relaxation data confirm the tight binding between the ligand and SH3 part of the chimera. This chimera will serve as a tool for a deeper understanding of the relationship between structure and thermodynamics of binding using a combination of NMR, stability and site-directed mutagenesis studies, which can lead to an effective strategy for ligand design.
-===Chimer between Spc-SH3 and P41===
+The high-resolution NMR structure of a single-chain chimeric protein mimicking a SH3-peptide complex.,Candel AM, Conejero-Lara F, Martinez JC, van Nuland NA, Bruix M FEBS Lett. 2007 Feb 20;581(4):687-92. Epub 2007 Jan 22. PMID:17275816<ref>PMID:17275816</ref>
-{{ABSTRACT_PUBMED_17275816}}
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-==About this Structure==
+<div class="pdbe-citations 2jmc" style="background-color:#fffaf0;"></div>
-[[2jmc]] is a 1 chain structure of [[Spectrin]] with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JMC OCA].
 ==See Also==
-*[[Spectrin|Spectrin]]
+*[[Spectrin 3D structures|Spectrin 3D structures]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:017275816</ref><references group="xtra"/>
+__TOC__
+</StructureSection>
 [[Category: Gallus gallus]]
-[[Category: Bruix, M.]]
+[[Category: Large Structures]]
-[[Category: Candel, A M.]]
+[[Category: Bruix M]]
-[[Category: Conejero-Lara, F.]]
+[[Category: Candel AM]]
-[[Category: Martinez, J C.]]
+[[Category: Conejero-Lara F]]
-[[Category: Nuland, N A.J van.]]
+[[Category: Martinez JC]]
-[[Category: Chimer]]
+[[Category: Van Nuland NAJ]]
-[[Category: P41]]
-[[Category: Signaling protein]]
-[[Category: Spc-sh3]]