2eha: Difference between revisions

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-[[Image:2eha.png|left|200px]]
-{{STRUCTURE_2eha|  PDB=2eha  |  SCENE=  }}
+==Crystal structure of goat lactoperoxidase complexed with formate anion at 3.3 A resolution==
+<StructureSection load='2eha' size='340' side='right'caption='[[2eha]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
-===Crystal structure of goat lactoperoxidase complexed with formate anion at 3.3 A resolution===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2eha]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Capra_hircus Capra hircus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EHA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EHA FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
-==About this Structure==
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=OSM:1-(OXIDOSULFANYL)METHANAMINE'>OSM</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
-[[2eha]] is a 2 chain structure of [[Lactoperoxidase]] with sequence from [http://en.wikipedia.org/wiki/Capra_hircus Capra hircus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EHA OCA].
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2eha FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eha OCA], [https://pdbe.org/2eha PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2eha RCSB], [https://www.ebi.ac.uk/pdbsum/2eha PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2eha ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PERL_CAPHI PERL_CAPHI] Antimicrobial agent which utilizes hydrogen peroxide and thiocyanate (SCN) to generate the antimicrobial substance hypothiocyanous acid (HOSCN) (PubMed:10894086). May protect the udder from infection and promote growth in newborns. Inhibits growth of several fungi including A.niger, Trichoderma species, C.cassicola, P.meadii and C.salmonicolor (PubMed:10894086). Does not have anti-fungal activity towards C.albicans and Pythium species (PubMed:10894086). Inhibits growth of several Gram-positive bacteria including some Staphylococcus species and Gram-negative bacteria including E.coli, P.aeruginosa and some Salmonella species (PubMed:10894086).<ref>PMID:10894086</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eh/2eha_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2eha ConSurf].
+<div style="clear:both"></div>
 ==See Also==
 *[[Lactoperoxidase|Lactoperoxidase]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Capra hircus]]
-[[Category: Peroxidase]]
+[[Category: Large Structures]]
-[[Category: Ethayathulla, A S.]]
+[[Category: Ethayathulla AS]]
-[[Category: Kaur, P.]]
+[[Category: Kaur P]]
-[[Category: Sharma, S.]]
+[[Category: Sharma S]]
-[[Category: Singh, A K.]]
+[[Category: Singh AK]]
-[[Category: Singh, N.]]
+[[Category: Singh N]]
-[[Category: Singh, T P.]]
+[[Category: Singh TP]]
-[[Category: Anti-microbail]]
-[[Category: Oxidoreductase]]