2nx7: Difference between revisions

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-{{Seed}}
-[[Image:2nx7.png|left|200px]]
-<!--
+==Structure of NOWA cysteine rich domain 8==
-The line below this paragraph, containing "STRUCTURE_2nx7", creates the "Structure Box" on the page.
+<StructureSection load='2nx7' size='340' side='right'caption='[[2nx7]]' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2nx7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Hydra_vulgaris Hydra vulgaris]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NX7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NX7 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 10 models</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nx7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nx7 OCA], [https://pdbe.org/2nx7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nx7 RCSB], [https://www.ebi.ac.uk/pdbsum/2nx7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nx7 ProSAT]</span></td></tr>
-{{STRUCTURE_2nx7|  PDB=2nx7  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q8IT70_HYDVU Q8IT70_HYDVU]
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The nematocyst wall of cnidarians is a unique biomaterial that withstands extreme osmotic pressures, allowing an ultrafast discharge of the nematocyst capsules. Assembly of the highly robust nematocyst wall is achieved by covalent linkage of cysteine-rich domains (CRDs) from two main protein components, minicollagens and nematocyst outer wall antigen (NOWA). The bipolar minicollagens have different disulfide patterns and topologies in their N and C-terminal CRDs. The functional significance of this polarity has been elusive. Here, we show by NMR structural analysis that all representative cysteine-rich domains of NOWA are structurally related to N-terminal minicollagen domains. Natural sequence insertions in NOWA CRDs have very little effect on the tightly knit domain structures, nor do they preclude the efficient folding to a single native conformation. The different folds in NOWA CRDs and the atypical C-terminal minicollagen domain on the other hand can be directly related to different conformational preferences in the reduced states. Ultrastructural analysis in conjunction with aggregation studies argues for an association between the similar NOWA and N-terminal minicollagen domains in early stages of the nematocyst wall assembly, which is followed by the controlled association between the unusual structures of C-terminal minicollagen domains.
-===Structure of NOWA cysteine rich domain 8===
+Sequence-structure and structure-function analysis in cysteine-rich domains forming the ultrastable nematocyst wall.,Meier S, Jensen PR, Adamczyk P, Bachinger HP, Holstein TW, Engel J, Ozbek S, Grzesiek S J Mol Biol. 2007 May 4;368(3):718-28. Epub 2007 Feb 24. PMID:17362991<ref>PMID:17362991</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-<!--
+</div>
-The line below this paragraph, {{ABSTRACT_PUBMED_17362991}}, adds the Publication Abstract to the page
+<div class="pdbe-citations 2nx7" style="background-color:#fffaf0;"></div>
-(as it appears on PubMed at http://www.pubmed.gov), where 17362991 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_17362991}}
+__TOC__
+</StructureSection>
-==About this Structure==
-NX7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Hydra_vulgaris Hydra vulgaris]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NX7 OCA].
-==Reference==
-Sequence-structure and structure-function analysis in cysteine-rich domains forming the ultrastable nematocyst wall., Meier S, Jensen PR, Adamczyk P, Bachinger HP, Holstein TW, Engel J, Ozbek S, Grzesiek S, J Mol Biol. 2007 May 4;368(3):718-28. Epub 2007 Feb 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17362991 17362991]
 [[Category: Hydra vulgaris]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Adamczyk, P.]]
+[[Category: Adamczyk P]]
-[[Category: Bachinger, H P.]]
+[[Category: Bachinger HP]]
-[[Category: Engel, J.]]
+[[Category: Engel J]]
-[[Category: Grzesiek, S.]]
+[[Category: Grzesiek S]]
-[[Category: Holstein, T W.]]
+[[Category: Holstein TW]]
-[[Category: Jensen, P R.]]
+[[Category: Jensen PR]]
-[[Category: Meier, S.]]
+[[Category: Meier S]]
-[[Category: Ozbek, S.]]
+[[Category: Ozbek S]]
-[[Category: Cysteine rich]]
-[[Category: Disulfide bond]]
-[[Category: Rich in turn]]
-[[Category: Structural protein]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:57:23 2008''