3b84: Difference between revisions

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-{{Seed}}
-[[Image:3b84.png|left|200px]]
-<!--
+==Crystal structure of the human BTB domain of the Krueppel related Zinc Finger Protein 3 (HKR3)==
-The line below this paragraph, containing "STRUCTURE_3b84", creates the "Structure Box" on the page.
+<StructureSection load='3b84' size='340' side='right'caption='[[3b84]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3b84]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B84 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3B84 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.74&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-{{STRUCTURE_3b84|  PDB=3b84  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3b84 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b84 OCA], [https://pdbe.org/3b84 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3b84 RCSB], [https://www.ebi.ac.uk/pdbsum/3b84 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3b84 ProSAT]</span></td></tr>
+</table>
-===Crystal structure of the human BTB domain of the Krueppel related Zinc Finger Protein 3 (HKR3)===
+== Function ==
+[https://www.uniprot.org/uniprot/TZAP_HUMAN TZAP_HUMAN] Telomere-binding protein that acts as a regulator of telomere length (PubMed:28500257, PubMed:28082411). Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat (PubMed:28500257, PubMed:28082411). Preferentially binds to telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres (PubMed:28082411). Also acts as a transcription regulator that binds to promoter regions (PubMed:7969177, PubMed:24382891, PubMed:28500257). Regulates expression of a small subset of genes, including MTFP1 (PubMed:28500257). Regulates expression the J and/or S elements in MHC II promoter (PubMed:7969177). Acts as a negative regulator of cell proliferation by specifically activating expression of ARF, a tumor suppressor isoform of CDKN2A (PubMed:24382891).<ref>PMID:24382891</ref> <ref>PMID:28082411</ref> <ref>PMID:28500257</ref> <ref>PMID:7969177</ref>
+== Evolutionary Conservation ==
-==About this Structure==
+[[Image:Consurf_key_small.gif|200px|right]]
-B84 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B84 OCA].
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b8/3b84_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3b84 ConSurf].
+<div style="clear:both"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Arrowsmith, C H.]]
+[[Category: Large Structures]]
-[[Category: Bullock, A.]]
+[[Category: Arrowsmith CH]]
-[[Category: Cooper, C.]]
+[[Category: Bullock A]]
-[[Category: Delft, F von.]]
+[[Category: Cooper C]]
-[[Category: Edwards, A M.]]
+[[Category: Edwards AM]]
-[[Category: Filippakopoulos, P.]]
+[[Category: Filippakopoulos P]]
-[[Category: Keates, T.]]
+[[Category: Keates T]]
-[[Category: Knapp, S.]]
+[[Category: Knapp S]]
-[[Category: Pike, A C.W.]]
+[[Category: Pike ACW]]
-[[Category: Pilka, E.]]
+[[Category: Pilka E]]
-[[Category: SGC, Structural Genomics Consortium.]]
+[[Category: Salah E]]
-[[Category: Salah, E.]]
+[[Category: Weigelt J]]
-[[Category: Weigelt, J.]]
+[[Category: Von Delft F]]
-[[Category: Activator]]
-[[Category: Btb]]
-[[Category: Dna-binding]]
-[[Category: Hkr3]]
-[[Category: Krueppel related zinc finger protein 3]]
-[[Category: Metal-binding]]
-[[Category: Nucleus]]
-[[Category: Oncogene]]
-[[Category: Sgc]]
-[[Category: Structural genomics consortium]]
-[[Category: Transcription]]
-[[Category: Transcription regulation]]
-[[Category: Zbtb48]]
-[[Category: Zinc finger]]
-[[Category: Zinc-finger]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 10:09:40 2009''