2jbx: Difference between revisions

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-{{Seed}}
-[[Image:2jbx.png|left|200px]]
-<!--
+==Crystal Structure of the myxoma virus anti-apoptotic protein M11L==
-The line below this paragraph, containing "STRUCTURE_2jbx", creates the "Structure Box" on the page.
+<StructureSection load='2jbx' size='340' side='right'caption='[[2jbx]], [[Resolution|resolution]] 2.73&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2jbx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Myxoma_virus Myxoma virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JBX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JBX FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.73&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-{{STRUCTURE_2jbx|  PDB=2jbx  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jbx OCA], [https://pdbe.org/2jbx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jbx RCSB], [https://www.ebi.ac.uk/pdbsum/2jbx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jbx ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q85295_9POXV Q85295_9POXV]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jb/2jbx_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jbx ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Many viruses express antiapoptotic proteins to counter host defense mechanisms that would otherwise trigger the rapid clearance of infected cells. For example, adenoviruses and some gamma-herpesviruses express homologs of prosurvival Bcl-2 to subvert the host's apoptotic machinery. Myxoma virus, a double-stranded DNA virus of the pox family, harbors antiapoptotic M11L, its virulence factor. Analysis of its three-dimensional structure reveals that despite lacking any primary sequence similarity to Bcl-2, it adopts a virtually identical protein fold. This allows it to associate with BH3 domains, especially those of Bax and Bak. We found that M11L acts primarily by sequestering Bax and Bak, thereby blocking the killing action of these essential cell-death mediators. These findings expand the family of protein sequences that act like Bcl-2 to block apoptosis and support the conclusion that the prosurvival action of these proteins critically depends on their ability to bind and antagonize Bax and/or Bak.
-===CRYSTAL STRUCTURE OF THE MYXOMA VIRUS ANTI-APOPTOTIC PROTEIN M11L===
+A structural viral mimic of prosurvival Bcl-2: a pivotal role for sequestering proapoptotic Bax and Bak.,Kvansakul M, van Delft MF, Lee EF, Gulbis JM, Fairlie WD, Huang DC, Colman PM Mol Cell. 2007 Mar 23;25(6):933-42. PMID:17386268<ref>PMID:17386268</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 2jbx" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_17386268}}, adds the Publication Abstract to the page
+*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 17386268 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_17386268}}
+__TOC__
+</StructureSection>
-==About this Structure==
+[[Category: Large Structures]]
-JBX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Myxoma_virus Myxoma virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JBX OCA].
-==Reference==
-A structural viral mimic of prosurvival Bcl-2: a pivotal role for sequestering proapoptotic Bax and Bak., Kvansakul M, van Delft MF, Lee EF, Gulbis JM, Fairlie WD, Huang DC, Colman PM, Mol Cell. 2007 Mar 23;25(6):933-42. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17386268 17386268]
-[[Category: Myxoma virus]]
-[[Category: Single protein]]
-[[Category: Colman, P M.]]
-[[Category: Delft, M F.Van.]]
-[[Category: Fairlie, W D.]]
-[[Category: Gulbis, J M.]]
-[[Category: Huang, D C.S.]]
-[[Category: Kvansakul, M.]]
-[[Category: Lee, E F.]]
-[[Category: Apoptosis]]
-[[Category: Bcl-2 family]]
 [[Category: Myxoma virus]]
+[[Category: Colman PM]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:29:07 2008''
+[[Category: Fairlie WD]]
+[[Category: Gulbis JM]]
+[[Category: Huang DCS]]
+[[Category: Kvansakul M]]
+[[Category: Lee EF]]
+[[Category: Van Delft MF]]